| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Microbiology |
| Manuscript Type |
Basic Study |
| Article Title |
Effect and mechanism of the Qingre Huashi Decoction on drug-resistance Helicobacter pylori through nonspecific pathways
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Miao-Miao Lin, Shan-Shan Yang, Qiu-Yue Huang, Guang-Hui Cui, Xiao-Fen Jia, Yao Yang, Zong-Ming Shi, Hui Ye and Xue-Zhi Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (General Program) |
81973615 |
| National Natural Science Foundation of China (General Program) |
82304930 |
| National Natural Science Foundation of Beijing |
7332323 |
| Capital’ s Funds for Health Improvement and Research |
CF2022-2-40711 |
|
| Corresponding Author |
Xue-Zhi Zhang, MD, PhD, Chief Physician, Professor, Department of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China. zhang.xuezhi@263.net |
| Key Words |
Qingre Huashi Decoction; Helicobacter pylori; Drug resistance; Biofilm; Metabolomics |
| Core Tip |
Helicobacter pylori (HP) infection affects over 4.4 billion people worldwide, with its multidrug resistance posing a serious challenge. Twelve strains of HP were isolated in vitro following biopsy during gastroscopy of HP-infected patients, with the most robust biofilm-forming strain of HP being selected to investigate the effect and mechanism of Qingre Huashi Decoction (QHD) on drug-resistance HP through nonspecific pathways. QHD has bacteriostatic and bactericidal effects on HP, reduces HP drug-resistance by inhibiting biofilm formation, destroying biofilm structure, inhibiting biofilm-related and efflux pump-related gene expression, enhancing HP metabolism, and activating AMP in HP. |
| Publish Date |
2024-06-25 10:41 |
| Citation |
Lin MM, Yang SS, Huang QY, Cui GH, Jia XF, Yang Y, Shi ZM, Ye H, Zhang XZ. Effect and mechanism of the Qingre Huashi Decoction on drug-resistance Helicobacter pylori through nonspecific pathways. World J Gastroenterol 2024; 30(24): 3086-3105 |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i24/3086.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i24.3086 |
