Publication Name	World Journal of Gastroenterology
Manuscript ID	93326
Country	Taiwan

Received	2024-02-24 22:54
Peer-Review Started	2024-02-24 22:54
To Make the First Decision
Return for Revision	2024-04-17 20:42
Revised	2024-04-30 06:42
Second Decision	2024-05-24 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-05-24 07:04
Articles in Press	2024-05-24 07:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-05-29 08:39
Publish the Manuscript Online	2024-06-21 03:14

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Medicine, General & Internal
Manuscript Type	Editorial
Article Title	Understanding the molecular crossroads in acute liver failure: A pathway to new therapies
Manuscript Source	Invited Manuscript
All Author List	Chun-Yao Cheng, Wen-Rui Hao and Tzu-Hurng Cheng
Funding Agency and Grant Number	Funding Agency Grant Number China Medical University CMU111-MF-10
Corresponding Author	Tzu-Hurng Cheng, PhD, Professor, Department of Biochemistry, School of Medicine, College of Medicine, China Medical University, No. 91 Xueshi Road, North District, Taichung 404333, Taiwan. thcheng@mail.cmu.edu.tw
Key Words	Silent information regulator sirtuin 1; Ferroptosis; Pyroptosis; P53/glutathione peroxidase 4/gasdermin D; Acute liver failure
Core Tip	Understanding the interplay between ferroptosis and pyroptosis is crucial for delineating the complex pathophysiology of acute liver failure (ALF). Targeting key regulators of these cell death pathways, particularly SIRT1, holds promise for the development of novel therapeutic strategies for mitigating hepatocyte injury and improving clinical outcomes in patients with ALF. Multidisciplinary collaborations that integrate basic science, translational research, and clinical trials should be conducted to accelerate the translation of the experimental findings into effective treatments for this life-threatening condition.
Publish Date	2024-06-21 03:14
Citation	<p>Cheng CY, Hao WR, Cheng TH. Understanding the molecular crossroads in acute liver failure: A pathway to new therapies. <i>World J Gastroenterol</i> 2024; 30(23): 2931-2933</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i23/2931.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i23.2931

Full Article (PDF)	WJG-30-2931-with-cover.pdf
Manuscript File	93326_Auto_Edited-YJP.docx
Answering Reviewers	93326-answering-reviewers.pdf
Audio Core Tip	93326-audio.mp3
Conflict-of-Interest Disclosure Form	93326-conflict-of-interest-statement.pdf
Copyright License Agreement	93326-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	93326-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	93326-non-native-speakers.pdf
Peer-review Report	93326-peer-reviews.pdf
Scientific Misconduct Check	93326-scientific-misconduct-check.png
Scientific Editor Work List	93326-scientific-editor-work-list.pdf
CrossCheck Report	93326-crosscheck-report.png
CrossCheck Report	93326-crosscheck-report.pdf