Publication Name	World Journal of Gastroenterology
Manuscript ID	93404
Country	Italy

Received	2024-02-29 09:43
Peer-Review Started	2024-02-29 09:43
To Make the First Decision
Return for Revision	2024-04-18 21:16
Revised	2024-04-24 16:05
Second Decision	2024-05-09 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-05-09 03:06
Articles in Press	2024-05-09 03:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-05-27 15:42
Publish the Manuscript Online	2024-05-27 09:35

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Metadherin-driven promotion of cancer stem cell phenotypes and its effect on immunity in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Nevena Todorović and Amedeo Amedei
Funding Agency and Grant Number
Corresponding Author	Amedeo Amedei, MSc, Full Professor, Department of Experimental and Clinical Medicine, University of Florence, 3 Largo Brambilla, Florence 50134, Italy. amedeo.amedei@unifi.it
Key Words	Hepatocellular carcinoma; Metadherin; Astrocyte elevated gene-1; Lysine rich CEACAM1; Cancer stem cell; Immunity
Core Tip	Metadherin (MTDH) is a protein and a predictor of poor prognosis, of aggressive tumor phenotypes prone to metastasis, recurrence, and therapy resistance in hepatocellular carcinoma (HCC). Several studies have demonstrated a correlation between MTDH and cancer stem cells, which has elevated interest in further investigating this oncogene and its impacts to a higher level. The editorial highlights the ongoing research in the HCC field, revealing the significance for future studies.
Publish Date	2024-05-27 09:35
Citation	<p>Todorović N, Amedei A. Metadherin-driven promotion of cancer stem cell phenotypes and its effect on immunity in hepatocellular carcinoma. <i>World J Gastroenterol</i> 2024; 30(20): 2624-2628</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i20/2624.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i20.2624

Full Article (PDF)	WJG-30-2624-with-cover.pdf
Manuscript File	93404_Auto_Edited-YJP.docx
Answering Reviewers	93404-Answering reviewers.pdf
Audio Core Tip	93404-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	93404-Conflict-of-interest statement.pdf
Copyright License Agreement	93404-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	93404-Language certificate.pdf
Peer-review Report	93404-Peer-review(s).pdf
Scientific Misconduct Check	93404-Bing-Chen YL-2.png
Scientific Editor Work List	93404-Scientific editor work list.pdf
CrossCheck Report	93404-CrossCheck report.pdf