| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Basic Study |
| Article Title |
Preclinical and clinical evidence of the association of colibactin-producing Escherichia coli with anxiety and depression in colon cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fabien Rondepierre, Maëva Meynier, Johan Gagniere, Vincent Deneuvy, Anissa Deneuvy, Gwenaelle Roche, Elodie Baudu, Bruno Pereira, Richard Bonnet, Nicolas Barnich, Frédéric Antonio Carvalho, Denis Pezet, Mathilde Bonnet and Isabelle Jalenques |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the French patient’s association against cancer (ligue contre le cancer) |
00001005238 |
| the French government IDEX-ISITE initiative |
16-IDEX-0001-CAP 20-25 |
| CPER (Nex-N-Mob) |
|
| the Auvergne-Rhône-Alpes region (“Thématiques émergentes”) |
AV0004111 |
| the Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation, INSERM, University of Clermont Auvergne [UMR1071, UMR1107], INRAE [USC-1382] |
|
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| Corresponding Author |
Mathilde Bonnet, PhD, Professor, M2iSH, UMR 1071, INSERM, University of Clermont Auvergne, INRAE USC 1382, 28 Place Henri Dunant, Clermont-Ferrand 63001, France. mathilde.bonnet@uca.fr |
| Key Words |
Colorectal cancer; Colibactin; Escherichia coli; Colibactin-producing Escherichia coli; Inflammation; Anxiety; Depression; Behavior |
| Core Tip |
Colibactin-producing Escherichia coli (CoPEC) have been associated to colorectal carcinogenesis. We demonstrated that all colorectal cancer patients colonized by CoPEC had psychiatric disorders that occurred several years before colorectal cancer diagnosis. Mice chronically infected with a CoPEC strain exhibited a significant increase of anxiety-/depressive-like behaviors in several tests. These first results suggest that CoPEC infection could induce microbiota-gut-brain axis disturbances in addition to their pro-carcinogenic properties. |
| Publish Date |
2024-06-03 08:49 |
| Citation |
<p>Rondepierre F, Meynier M, Gagniere J, Deneuvy V, Deneuvy A, Roche G, Baudu E, Pereira B, Bonnet R, Barnich N, Carvalho FA, Pezet D, Bonnet M, Jalenques I. Preclinical and clinical evidence of the association of colibactin-producing Escherichia coli with anxiety and depression in colon cancer. <i>World J Gastroenterol</i> 2024; 30(21): 2817-2826</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i21/2817.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i21.2817 |
