Publication Name	World Journal of Diabetes
Manuscript ID	93578
Country	China

Received	2024-03-01 09:37
Peer-Review Started	2024-03-01 09:37
To Make the First Decision
Return for Revision	2024-05-22 05:18
Revised	2024-06-03 09:47
Second Decision	2024-06-25 06:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-07-05 07:02
Articles in Press	2024-07-05 07:02
Publication Fee Transferred	2024-07-08 08:51
Edit the Manuscript by Language Editor	2024-07-15 03:32
Typeset the Manuscript	2024-07-19 05:36
Publish the Manuscript Online	2024-07-26 06:56

ISSN	1948-9358 (online)
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Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Intestinal glucagon-like peptide-1: A new player associated with impaired counterregulatory responses to hypoglycaemia in type 1 diabetic mice
Manuscript Source	Unsolicited Manuscript
All Author List	Fang-Xin Jin, Yan Wang, Min-Ne Li, Ru-Jiang Li and Jun-Tang Guo
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81471048
Corresponding Author	Ru-Jiang Li, MD, Professor, Department of Histology and Embryology, Key Laboratory of Universities in Shandong Province, Shandong Second Medical University, No. 7166 Baotong West Street, Weifang 261053, Shandong Province, China. nuliluck@163.com
Key Words	Glucagon-like peptide-1; Impaired hypoglycaemic counterregulation; Type 1 diabetes; Intestine; Pancreas
Core Tip	Glucagon-like peptide-1 (GLP-1) is an incretin hormone primarily produced by specific enteroendocrine L-cells in the intestines. The role of GLP-1 on impaired hypoglycaemic counterregulation in type 1 diabetes mellitus (T1DM) has not been reported. In this study, a model of recurrent hypoglycaemia in T1DM mice was established, and it was found that excessive intestinal GLP-1 is strongly associated with impaired counterregulatory responses to hypoglycaemia, leading to reduced appetite and compromised secretion of adrenaline, noradrenaline, and glucagon during hypoglycaemia.
Publish Date	2024-07-26 06:56
Citation	<p>Jin FX, Wang Y, Li MN, Li RJ, Guo JT. Intestinal glucagon-like peptide-1: A new player associated with impaired counterregulatory responses to hypoglycaemia in type 1 diabetic mice. <i>World J Diabetes</i> 2024; 15(8): 1764-1777</p>
URL	https://www.wjgnet.com/1948-9358/full/v15/i8/1764.htm
DOI	https://dx.doi.org/10.4239/wjd.v15.i8.1764

Full Article (PDF)	WJD-15-1764-with-cover.pdf
The ARRIVE Guidelines	93578-The-ARRIVE-Guidelines.pdf
Manuscript File	93578_Auto_Edited_071522.docx
Answering Reviewers	93578-answering-reviewers.pdf
Audio Core Tip	93578-audio.mp3
Biostatistics Review Certificate	93578-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	93578-conflict-of-interest-statement.pdf
Copyright License Agreement	93578-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	93578-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	93578-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	93578-non-native-speakers.pdf
Supplementary Material	93578-supplementary-material.pdf
Peer-review Report	93578-peer-reviews.pdf
Journal Editor-in-Chief Review Report	93578-journal-editor-in-chief.pdf
Scientific Misconduct Check	93578-scientific-misconduct-check.png
Scientific Editor Work List	93578-scientific-editor-work-list.pdf
CrossCheck Report	93578-crosscheck-report.png
CrossCheck Report	93578-crosscheck-report.pdf