Publication Name	World Journal of Clinical Oncology
Manuscript ID	93670
Country	China

Received	2024-03-03 14:13
Peer-Review Started	2024-03-03 14:13
To Make the First Decision
Return for Revision	2024-08-25 15:27
Revised	2024-09-04 17:33
Second Decision	2024-10-11 02:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-11 09:52
Articles in Press	2024-10-11 09:52
Publication Fee Transferred	2024-10-23 12:34
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-10-29 02:34
Publish the Manuscript Online	2024-10-30 10:06

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Retrospective Cohort Study
Article Title	Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine
Manuscript Source	Unsolicited Manuscript
All Author List	Jiang-Yu Bian, Yu-Fang Feng, Wen-Ting He and Tong Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82174461 Hospital Capability Enhancement Project of Xiyuan Hospital, CACMS XYZX0201-22 Technology Innovation Project of China Academy of Chinese Medical Sciences CI2021A01811
Corresponding Author	Tong Zhang, MD, Associate Chief Physician, Department of Oncology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, No. 1 Xiyuan Playground, Haidian District, Beijing 100091, China. ashtray7654@126.com
Key Words	Metastatic colorectal cancer; BRAF V600E mutation; Integrated Chinese and Western medicine; Cohort study
Core Tip	Patients with BRAF V600E mutant metastatic colorectal cancer (mCRC) have a much lower median overall survival than patients without BRAF V600E mutations. This study employed a retrospective cohort design and confirmed that in the real world, compared to chemotherapy and/or targeted therapy, combined treatment with integrated Chinese and Western medicine significantly extended overall survival and reduced the risk of death in BRAF V600E mutated mCRC patients, while being more effective in patients involving right colon, liver metastases, combined chemotherapy, and first-line therapy.
Publish Date	2024-10-30 10:06
Citation	<p>Bian JY, Feng YF, He WT, Zhang T. Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine. <i>World J Clin Oncol</i> 2025; 16(1): 93670</p>
URL	https://www.wjgnet.com/2218-4333/full/v16/i1/93670.htm
DOI	https://dx.doi.org/10.5306/wjco.v16.i1.93670

Full Article (PDF)	WJCO-16-93670-with-cover.pdf
STROBE Statement	93670-STROBE-statement.pdf
Manuscript File	93670_Auto_Edited_033328.docx
Answering Reviewers	93670-answering-reviewers.pdf
Audio Core Tip	93670-audio.mp3
Biostatistics Review Certificate	93670-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	93670-conflict-of-interest-statement.pdf
Copyright License Agreement	93670-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	93670-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	93670-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	93670-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	93670-non-native-speakers.pdf
Peer-review Report	93670-peer-reviews.pdf
Scientific Misconduct Check	93670-scientific-misconduct-check.png
Scientific Editor Work List	93670-scientific-editor-work-list.pdf
CrossCheck Report	93670-crosscheck-report.pdf