Publication Name	World Journal of Stem Cells
Manuscript ID	93733
Country	China

Received	2024-03-04 14:30
Peer-Review Started	2024-03-04 14:30
To Make the First Decision
Return for Revision	2024-08-10 20:21
Revised	2024-08-20 15:23
Second Decision	2024-09-02 02:43
Accepted by Journal Editor-in-Chief	2024-09-05 05:51
Accepted by Executive Editor-in-Chief	2024-09-06 09:02
Articles in Press	2024-09-06 09:02
Publication Fee Transferred	2024-09-07 14:00
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-09-19 07:22
Publish the Manuscript Online	2024-11-26 10:21

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Yes-associated protein-mediated melatonin regulates the function of periodontal ligament stem cells under oxidative stress conditions
Manuscript Source	Unsolicited Manuscript
All Author List	Ke Gu, Xiao-Mei Feng, Shao-Qing Sun, Xing-Yao Hao and Yong Wen
Funding Agency and Grant Number	Funding Agency Grant Number Open Foundation of Shandong Key Laboratory of Oral Tissue Regeneration SDDX202001 Shandong Provincial Natural Science Foundation ZR2021MH075 Clinical Research Center of Shandong University 2020SDUCRCC006
Corresponding Author	Yong Wen, Doctor, PhD, Professor, Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, No. 44 Wenhua West Road, Jinan 250012, Shandong Province, China. wenyong@sdu.edu.cn
Key Words	Human periodontal ligament stem cells; Melatonin; Reactive oxygen species; Senescence; Yes-associated protein
Core Tip	While the use of mesenchymal stem cells in preclinical and clinical studies for the treatment of various diseases has provided promising results, the microenvironment of oxidative stress inhibits the efficacy of mesenchymal stem cells-mediated tissue regeneration, which remains a major challenge limiting clinical applications. Our findings provide new insights into melatonin (MT) regulation in the biological functions of oxidative stress-induced periodontal ligament stem cells and elucidate the potential mechanism of Yes-associated protein-mediated MT action. These findings strengthen our comprehension of the role of MT during cellular oxidative stress and provide potential targets for the development of new therapeutic strategies to promote tissue regeneration.
Publish Date	2024-11-26 10:21
Citation	<p>Gu K, Feng XM, Sun SQ, Hao XY, Wen Y. Yes-associated protein-mediated melatonin regulates the function of periodontal ligament stem cells under oxidative stress conditions. <i>World J Stem Cells</i> 2024; 16(11): 926-943</p>
URL	https://www.wjgnet.com/1948-0210/full/v16/i11/926.htm
DOI	https://dx.doi.org/10.4252/wjsc.v16.i11.926

Full Article (PDF)	WJSC-16-926-with-cover.pdf
Manuscript File	93733_Auto_Edited_013904.docx
Answering Reviewers	93733-answering-reviewers.pdf
Audio Core Tip	93733-audio.mp3
Biostatistics Review Certificate	93733-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	93733-conflict-of-interest-statement.pdf
Copyright License Agreement	93733-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	93733-foundation-statement.pdf
Institutional Review Board Approval Form or Document	93733-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	93733-non-native-speakers.pdf
Peer-review Report	93733-peer-reviews.pdf
Journal Editor-in-Chief Review Report	93733-journal-editor-in-chief.pdf
Scientific Misconduct Check	93733-scientific-misconduct-check.png
Scientific Editor Work List	93733-scientific-editor-work-list.pdf
CrossCheck Report	93733-crosscheck-report.pdf