| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Asiaticoside improves diabetic nephropathy by reducing inflammation, oxidative stress, and fibrosis: An in vitro and in vivo study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lan-Gen Zhuang, Rong Zhang, Guo-Xi Jin, Xiao-Yan Pei, Qiong Wang and Xiao-Xu Ge |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| General project of Anhui Provincial Health and Construction Commission |
No. AHWJ2022b056 |
|
| Corresponding Author |
Xiao-Xu Ge, MD, Doctor, Doctor, Department of Endocrinology, Tongren Hospital Affiliated to Shanghai Jiao Tong University, No. 1111 Xianxia Road, Changning District, Shanghai 200336, China. uyhyt41964@163.com |
| Key Words |
Asiaticoside; Diabetic nephropathy; Inflammation; Renal fibrosis; Reactive oxygen species |
| Core Tip |
This study investigates the protective effects of asiaticoside (AC) in diabetic nephropathy (DN) using in vitro and in vivo models. AC attenuated high glucose-induced proliferation, inflammation, oxidative stress, and fibrosis in rat glomerular mesangial cells. In a streptozotocin-induced DN rat model, AC ameliorated renal injury, reduced inflammatory cytokines, oxidative stress markers, and fibrogenic markers. Notably, the renoprotective effects of AC were associated with the activation of the nuclear factor erythroid 2-related factor 2 (NRF2)/heme oxygenase-1 antioxidant signaling pathway, suggesting AC’s therapeutic potential for DN by targeting inflammation, oxidative stress, and fibrosis through the NRF2 mechanism. |
| Publish Date |
2024-09-26 08:51 |
| Citation |
<p>Zhuang LG, Zhang R, Jin GX, Pei XY, Wang Q, Ge XX. Asiaticoside improves diabetic nephropathy by reducing inflammation, oxidative stress, and fibrosis: An in vitro and in vivo study. <i>World J Diabetes</i> 2024; 15(10): 2111-2122</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v15/i10/2111.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v15.i10.2111 |
