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6/6/2024 8:29:05 AM | Browse: 49 | Download: 63
Publication Name World Journal of Gastroenterology
Manuscript ID 93980
Country Mexico
2024-03-08 23:35
Peer-Review Started
2024-03-08 23:35
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Return for Revision
2024-04-25 07:52
2024-05-08 18:17
Second Decision
2024-05-24 02:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2024-05-24 04:44
Articles in Press
2024-05-24 04:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2024-05-30 06:35
Publish the Manuscript Online
2024-06-06 05:43
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Infectious Diseases
Manuscript Type Minireviews
Article Title Histopathological impact of SARS-CoV-2 on the liver: Cellular damage and long-term complications
Manuscript Source Invited Manuscript
All Author List Alfonso Rodriguez-Espada, Moisés Salgado-de la Mora, Briana Mariette Rodriguez-Paniagua, Nathaly Limon-de la Rosa, Monica Itzel Martínez-Gutiérrez, Santiago Pastrana-Brandes and Nalu Navarro-Alvarez
Funding Agency and Grant Number
Corresponding Author Nalu Navarro-Alvarez, MD, PhD, Assistant Professor, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 15 Vasco de Quiroga, Mexico 14080, Mexico. nalu.navarroa@incmnsz.mx
Key Words Liver; Severe acute respiratory syndrome coronavirus 2; Coronavirus disease 2019; Angiotensin-converting enzyme 2; Histopathology; Liver biopsies; Liver autopsy; In vitro
Core Tip Severe acute respiratory syndrome coronavirus 2 infection is linked to significant liver injury, emerging from the facilitated entry of the virus into liver cells, including cholangiocytes and endothelial cells, due to increased receptor expression. This invasion triggers critical cellular alterations such as mitochondrial swelling, endoplasmic reticulum dilation, and hepatocyte apoptosis. Confirmed by biopsy or autopsy, the presence of viral particles in liver tissues correlates with extensive histological damage, characterized by necrosis, steatosis, cholestasis, and inflammation. Such findings highlight the acute hepatic impact of coronavirus disease 2019 (COVID-19) and signal the risk of severe long-term complications, such as COVID-19-associated sclerosing cholangitis, emphasizing the profound and enduring effect of the virus on liver health.
Publish Date 2024-06-06 05:43
Citation <p>Rodriguez-Espada A, Salgado-de la Mora M, Rodriguez-Paniagua BM, Limon-de la Rosa N, Martínez-Gutiérrez MI, Pastrana-Brandes S, Navarro-Alvarez N. Histopathological impact of SARS-CoV-2 on the liver: Cellular damage and long-term complications. <i>World J Gastroenterol</i> 2024; 30(22): 2866-2880</p>
URL https://www.wjgnet.com/1007-9327/full/v30/i22/2866.htm
DOI https://dx.doi.org/10.3748/wjg.v30.i22.2866
Full Article (PDF) WJG-30-2866-with-cover.pdf
Manuscript File 93980_Auto_Edited-YJP.docx
Answering Reviewers 93980-answering-reviewers.pdf
Audio Core Tip 93980-audio.m4a
Conflict-of-Interest Disclosure Form 93980-conflict-of-interest-statement.pdf
Copyright License Agreement 93980-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 93980-non-native-speakers.pdf
Peer-review Report 93980-peer-reviews.pdf
Scientific Misconduct Check 93980-scientific-misconduct-check.jpg
Scientific Editor Work List 93980-scientific-editor-work-list.pdf
CrossCheck Report 93980-crosscheck-report.pdf