Publication Name	World Journal of Gastroenterology
Manuscript ID	93980
Country	Mexico

Received	2024-03-08 23:35
Peer-Review Started	2024-03-08 23:35
To Make the First Decision
Return for Revision	2024-04-25 07:52
Revised	2024-05-08 18:17
Second Decision	2024-05-24 02:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-05-24 04:44
Articles in Press	2024-05-24 04:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-05-30 06:35
Publish the Manuscript Online	2024-06-06 05:43

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Infectious Diseases
Manuscript Type	Minireviews
Article Title	Histopathological impact of SARS-CoV-2 on the liver: Cellular damage and long-term complications
Manuscript Source	Invited Manuscript
All Author List	Alfonso Rodriguez-Espada, Moisés Salgado-de la Mora, Briana Mariette Rodriguez-Paniagua, Nathaly Limon-de la Rosa, Monica Itzel Martínez-Gutiérrez, Santiago Pastrana-Brandes and Nalu Navarro-Alvarez
Funding Agency and Grant Number
Corresponding Author	Nalu Navarro-Alvarez, MD, PhD, Assistant Professor, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 15 Vasco de Quiroga, Mexico 14080, Mexico. nalu.navarroa@incmnsz.mx
Key Words	Liver; Severe acute respiratory syndrome coronavirus 2; Coronavirus disease 2019; Angiotensin-converting enzyme 2; Histopathology; Liver biopsies; Liver autopsy; In vitro
Core Tip	Severe acute respiratory syndrome coronavirus 2 infection is linked to significant liver injury, emerging from the facilitated entry of the virus into liver cells, including cholangiocytes and endothelial cells, due to increased receptor expression. This invasion triggers critical cellular alterations such as mitochondrial swelling, endoplasmic reticulum dilation, and hepatocyte apoptosis. Confirmed by biopsy or autopsy, the presence of viral particles in liver tissues correlates with extensive histological damage, characterized by necrosis, steatosis, cholestasis, and inflammation. Such findings highlight the acute hepatic impact of coronavirus disease 2019 (COVID-19) and signal the risk of severe long-term complications, such as COVID-19-associated sclerosing cholangitis, emphasizing the profound and enduring effect of the virus on liver health.
Publish Date	2024-06-06 05:43
Citation	<p>Rodriguez-Espada A, Salgado-de la Mora M, Rodriguez-Paniagua BM, Limon-de la Rosa N, Martínez-Gutiérrez MI, Pastrana-Brandes S, Navarro-Alvarez N. Histopathological impact of SARS-CoV-2 on the liver: Cellular damage and long-term complications. <i>World J Gastroenterol</i> 2024; 30(22): 2866-2880</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i22/2866.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i22.2866

Full Article (PDF)	WJG-30-2866-with-cover.pdf
Manuscript File	93980_Auto_Edited-YJP.docx
Answering Reviewers	93980-answering-reviewers.pdf
Audio Core Tip	93980-audio.m4a
Conflict-of-Interest Disclosure Form	93980-conflict-of-interest-statement.pdf
Copyright License Agreement	93980-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	93980-non-native-speakers.pdf
Peer-review Report	93980-peer-reviews.pdf
Scientific Misconduct Check	93980-scientific-misconduct-check.jpg
Scientific Editor Work List	93980-scientific-editor-work-list.pdf
CrossCheck Report	93980-crosscheck-report.pdf