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7/29/2024 10:32:04 AM | Browse: 192 | Download: 296
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Received |
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2024-03-10 12:52 |
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Peer-Review Started |
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2024-03-10 12:52 |
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To Make the First Decision |
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Return for Revision |
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2024-06-04 04:45 |
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Revised |
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2024-06-20 02:25 |
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Second Decision |
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2024-07-19 02:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-07-19 05:44 |
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Articles in Press |
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2024-07-19 05:44 |
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Publication Fee Transferred |
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2024-07-19 09:43 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-07-24 03:15 |
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Publish the Manuscript Online |
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2024-07-29 02:31 |
ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Endocrinology & Metabolism |
Manuscript Type |
Basic Study |
Article Title |
Leech Poecilobdella manillensis protein extract ameliorated hyperuricemia by restoring gut microbiota dysregulation and affecting serum metabolites
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Xia Liu, Xing-Qiu Liang, Tian-Cai Lu, Zhe Feng, Min Zhang, Nan-Qing Liao, Feng-Lian Zhang, Bo Wang and Li-Sheng Wang |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
National Natural Science Foundation of China |
82160843 |
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Corresponding Author |
Li-Sheng Wang, MD, PhD, Professor, Medical College, Guangxi University, No. 100 Daxue East Road, Nanning 530004, Guangxi Zhuang Autonomous Region, China. lswang@gxu.edu.cn |
Key Words |
Gut microbiota; Metabolism; Multi-omics; Poecilobdella manillensis; Sphingolipid metabolism pathway; Galactose metabolism pathway; Hyperuricemia |
Core Tip |
This study reveals the novel therapeutic potential of Poecilobdella manillensis in treating hyperuricemia (HUA) through a dual mechanism: The direct modulation of uric acid levels and restoration of renal and intestinal barriers. Importantly, it highlights the role of proteins in Poecilobdella manillensis in rectifying gut microbiota dysbiosis and adjusting key metabolic pathways, most notably, sphingolipid and galactose metabolism. These findings highlight the multi-target, multi-channel effects of Poecilobdella manillensis treatment for HUA and provide fundamental data for the clinical use of HUA treatments. |
Publish Date |
2024-07-29 02:31 |
Citation |
<p>Liu X, Liang XQ, Lu TC, Feng Z, Zhang M, Liao NQ, Zhang FL, Wang B, Wang LS. Leech Poecilobdella manillensis protein extract ameliorated hyperuricemia by restoring gut microbiota dysregulation and affecting serum metabolites. <i>World J Gastroenterol</i> 2024; 30(29): 3488-3510</p> |
URL |
https://www.wjgnet.com/1007-9327/full/v30/i29/3488.htm |
DOI |
https://dx.doi.org/10.3748/wjg.v30.i29.3488 |
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