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Publication Name World Journal of Gastroenterology
Manuscript ID 94050
Country China
Received
2024-03-10 12:52
Peer-Review Started
2024-03-10 12:52
To Make the First Decision
Return for Revision
2024-06-04 04:45
Revised
2024-06-20 02:25
Second Decision
2024-07-19 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2024-07-19 05:44
Articles in Press
2024-07-19 05:44
Publication Fee Transferred
2024-07-19 09:43
Edit the Manuscript by Language Editor
Typeset the Manuscript
2024-07-24 03:15
Publish the Manuscript Online
2024-07-29 02:31
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology & Metabolism
Manuscript Type Basic Study
Article Title Leech Poecilobdella manillensis protein extract ameliorated hyperuricemia by restoring gut microbiota dysregulation and affecting serum metabolites
Manuscript Source Unsolicited Manuscript
All Author List Xia Liu, Xing-Qiu Liang, Tian-Cai Lu, Zhe Feng, Min Zhang, Nan-Qing Liao, Feng-Lian Zhang, Bo Wang and Li-Sheng Wang
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 82160843
Corresponding Author Li-Sheng Wang, MD, PhD, Professor, Medical College, Guangxi University, No. 100 Daxue East Road, Nanning 530004, Guangxi Zhuang Autonomous Region, China. lswang@gxu.edu.cn
Key Words Gut microbiota; Metabolism; Multi-omics; Poecilobdella manillensis; Sphingolipid metabolism pathway; Galactose metabolism pathway; Hyperuricemia
Core Tip This study reveals the novel therapeutic potential of Poecilobdella manillensis in treating hyperuricemia (HUA) through a dual mechanism: The direct modulation of uric acid levels and restoration of renal and intestinal barriers. Importantly, it highlights the role of proteins in Poecilobdella manillensis in rectifying gut microbiota dysbiosis and adjusting key metabolic pathways, most notably, sphingolipid and galactose metabolism. These findings highlight the multi-target, multi-channel effects of Poecilobdella manillensis treatment for HUA and provide fundamental data for the clinical use of HUA treatments.
Publish Date 2024-07-29 02:31
Citation <p>Liu X, Liang XQ, Lu TC, Feng Z, Zhang M, Liao NQ, Zhang FL, Wang B, Wang LS. Leech Poecilobdella manillensis protein extract ameliorated hyperuricemia by restoring gut microbiota dysregulation and affecting serum metabolites. <i>World J Gastroenterol</i> 2024; 30(29): 3488-3510</p>
URL https://www.wjgnet.com/1007-9327/full/v30/i29/3488.htm
DOI https://dx.doi.org/10.3748/wjg.v30.i29.3488
Full Article (PDF) WJG-30-3488-with-cover.pdf
The ARRIVE Guidelines 94050-The-ARRIVE-Guidelines.pdf
Manuscript File 94050_Auto_Edited_022057.docx
Answering Reviewers 94050-answering-reviewers.pdf
Audio Core Tip 94050-audio.mp3
Biostatistics Review Certificate 94050-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 94050-conflict-of-interest-statement.pdf
Copyright License Agreement 94050-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 94050-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 94050-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate 94050-non-native-speakers.pdf
Supplementary Material 94050-supplementary-material.pdf
Peer-review Report 94050-peer-reviews.pdf
Scientific Misconduct Check 94050-scientific-misconduct-check.png
Scientific Editor Work List 94050-scientific-editor-work-list.pdf
CrossCheck Report 94050-crosscheck-report.pdf