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1/21/2025 9:40:07 AM | Browse: 65 | Download: 139
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Received |
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2024-03-11 10:01 |
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Peer-Review Started |
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2024-03-11 10:01 |
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To Make the First Decision |
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Return for Revision |
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2024-09-23 08:49 |
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Revised |
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2024-10-17 09:20 |
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Second Decision |
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2024-11-25 02:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-11-25 06:38 |
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Articles in Press |
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2024-11-25 06:38 |
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Publication Fee Transferred |
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2024-12-02 01:18 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-01-13 01:33 |
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Publish the Manuscript Online |
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2025-01-21 09:22 |
ISSN |
2218-4333 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Oncology |
Manuscript Type |
Basic Study |
Article Title |
Transmembrane channel-like 5 drives hepatocellular carcinoma progression by regulating epithelial-mesenchymal transition
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Jiao Li, Zi-Yu Wang, Yan Jin, Jing Xu, Yun-Jin Ya, Ting-Qiu Wan, Xi Li and Xi Wang |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
the Yunnan Provincial Department of Science and Technology-Kunming Medical University Joint Special Project on Applied Basic Research |
202401AY070001-132 |
the Yunnan Provincial Science Foundation |
2018FE001(-287) |
National Natural Science Foundation of China |
81460443 |
the Ten Thousand People Plan of Yunnan Province |
KH-SWR-MY-2020-002 |
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Corresponding Author |
Yan Jin, Chief Physician, Department of Hepatobiliary Surgery, The Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road,Xishan District, Kunming 650500, Yunnan Province, China. 13312503258@163.com |
Key Words |
Hepatocellular carcinoma; Transmembrane channel-like protein 5; Epithelial-mesenchymal transition; Bioinformatics; diagnosis; Prognosis |
Core Tip |
In this study, transmembrane channel-like 5 (TMC5), which is highly expressed in hepatocellular carcinoma (HCC) and associated with increased invasive migration ability, is proposed for the first time as a potential marker for HCC. Bioinformatics analysis and in vivo and in vitro experiments confirmed that TMC5 regulates epithelial-mesenchymal transition to promote invasive migration in HCC. TMC5 might be a valuable molecular target for HCC diagnosis and treatment. |
Publish Date |
2025-01-21 09:22 |
Citation |
<p>Li J, Wang ZY, Jin Y, Xu J, Ya YJ, Wan TQ, Li X, Wang X. Transmembrane channel-like 5 drives hepatocellular carcinoma progression by regulating epithelial-mesenchymal transition. <i>World J Clin Oncol</i> 2025; 16(3): 94091</p> |
URL |
https://www.wjgnet.com/2218-4333/full/v16/i3/94091.htm |
DOI |
https://dx.doi.org/10.5306/wjco.v16.i3.94091 |
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