Publication Name	World Journal of Gastroenterology
Manuscript ID	94092
Country	China

Received	2024-03-12 00:28
Peer-Review Started	2024-03-12 00:28
To Make the First Decision
Return for Revision	2024-09-16 16:21
Revised	2024-09-29 07:07
Second Decision	2024-10-12 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-12 07:05
Articles in Press	2024-10-12 07:05
Publication Fee Transferred	2024-10-12 08:20
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-10-17 02:29
Publish the Manuscript Online	2024-10-23 04:32

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Amino acid deletions at positions 893 and 894 of cytotoxin-associated gene A protein affect Helicobacter pylori gastric epithelial cell interactions
Manuscript Source	Unsolicited Manuscript
All Author List	Zhi-Jing Xue, Ya-Nan Gong, Li-Hua He, Lu Sun, Yuan-Hai You, Dong-Jie Fan, Mao-Jun Zhang, Xiao-Mei Yan and Jian-Zhong Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Shandong Medical and Health Science and Technology Development Plan Project No. 202202080452
Corresponding Author	Jian-Zhong Zhang, MD, PhD, Professor, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, No. 155 Changbai Road, Changping District, Beijing 102206, China. zhangjianzhong@icdc.cn
Key Words	Cytotoxin-associated gene A; Glu-Pro-Ile-Tyr-Ala; Hummingbird phenotype; Interleukin-8; Helicobacter pylori
Core Tip	The present study evaluated the impact of amino acid deletions at positions 893 and 894 on cytotoxin-associated gene A (CagA) protein function. Amino acid deletions at positions 893 and 894 enhance the ability of CagA to induce hummingbird cells, cytoskeletal rearrangement, and interleukin-8 secretion. This finding is crucial for elucidating the molecular mechanism of CagA protein pathogenicity and identifying biomarkers of highly pathogenic Helicobacter pylori.
Publish Date	2024-10-23 04:32
Citation	<p>Xue ZJ, Gong YN, He LH, Sun L, You YH, Fan DJ, Zhang MJ, Yan XM, Zhang JZ. Amino acid deletions at positions 893 and 894 of cytotoxin-associated gene A protein affect Helicobacter pylori gastric epithelial cell interactions. <i>World J Gastroenterol</i> 2024; 30(41): 4449-4460</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i41/4449.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i41.4449

Full Article (PDF)	WJG-30-4449-with-cover.pdf
Manuscript File	94092_Auto_Edited_072954.docx
Answering Reviewers	94092-answering-reviewers.pdf
Audio Core Tip	94092-audio.mp3
Biostatistics Review Certificate	94092-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	94092-conflict-of-interest-statement.pdf
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Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	94092-foundation-statement.pdf
Institutional Review Board Approval Form or Document	94092-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	94092-non-native-speakers.pdf
Peer-review Report	94092-peer-reviews.pdf
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Scientific Editor Work List	94092-scientific-editor-work-list.pdf
CrossCheck Report	94092-crosscheck-report.pdf