Publication Name	World Journal of Hepatology
Manuscript ID	94098
Country	United States

Received	2024-03-11 09:13
Peer-Review Started	2024-03-11 09:13
To Make the First Decision
Return for Revision	2024-04-29 19:32
Revised	2024-06-03 03:07
Second Decision	2024-06-27 02:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-06-27 08:03
Articles in Press	2024-06-27 08:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-07-10 02:25
Publish the Manuscript Online	2024-07-26 10:33

ISSN	1948-5182 (online)
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Category	Infectious Diseases
Manuscript Type	Retrospective Study
Article Title	Improvement of hepatic fibrosis after tenofovir disoproxil fumarate switching to tenofovir alafenamide for three years
Manuscript Source	Unsolicited Manuscript
All Author List	Tung Huynh, Delana MyAn Bui, Tina Xiwen Zhou and Ke-Qin Hu
Funding Agency and Grant Number
Corresponding Author	Ke-Qin Hu, FAASLD, MD, Director, Director, Professor, Director of Hepatology Services, Professor of Clinical Medicine, Division of Gastroenterology and Hepatology, University of California Irvine, School of Medicine, 101 The City Drive, Building 22C, Room 1503, Orange, CA 92868, United States. kqhu@uci.edu
Key Words	Tenofovir alafenamide; Tenofovir disoproxil fumarate; Switching; Hepatic fibrosis improvement; Aspartate aminotransferase to platelet ratio index; Fibrosis-4; Shear wave elastography
Core Tip	Tenofovir disoproxil fumarate (TDF), entecavir, and tenofovir alafenamide (TAF) have been used as first-line therapy for chronic hepatitis B. In this study, we assessed the effect of TDF switching to TAF for 3 years (144 weeks) on dynamic changes of alanine aminotransferase (ALT), aspartate aminotransferase (AST), AST to platelet ratio index (APRI), fibrosis-4 (FIB-4) scores and shear wave elastography (SWE) reading. Our study demonstrated that switching from TDF to TAF for 3 years results in persistent mean ALT and AST reduction with high rate of normalization, and also hepatic fibrosis improvement assessed by mean APRI and FIB-4 scores, as well as SWE reading.
Publish Date	2024-07-26 10:33
Citation	<p>Huynh T, Bui DM, Zhou TX, Hu KQ. Improvement of hepatic fibrosis after tenofovir disoproxil fumarate switching to tenofovir alafenamide for three years. <i>World J Hepatol</i> 2024; 16(7): 1009-1017</p>
URL	https://www.wjgnet.com/1948-5182/full/v16/i7/1009.htm
DOI	https://dx.doi.org/10.4254/wjh.v16.i7.1009

Full Article (PDF)	WJH-16-1009-with-cover.pdf
Manuscript File	94098_Auto_Edited-YJP.docx
Answering Reviewers	94098-answering-reviewers.pdf
Audio Core Tip	94098-audio.m4a
Biostatistics Review Certificate	94098-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	94098-conflict-of-interest-statement.pdf
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Institutional Review Board Approval Form or Document	94098-institutional-review-board-statement.pdf
Peer-review Report	94098-peer-reviews.pdf
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Scientific Editor Work List	94098-scientific-editor-work-list.pdf
CrossCheck Report	94098-crosscheck-report.pdf