| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Case Control Study |
| Article Title |
Association of serum interleukin-6 with negative symptoms in stable early-onset schizophrenia
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Peng Chen, Hai-Dong Yang, Jun-Jie Wang, Zhen-Hua Zhu, Hui-Min Zhao, Xu-Yuan Yin, Yuan Cai, Hong-Liang Zhu, Jia-Lin Fu, Xin-Zhu Zhang, Wen-Xi Sun, Li Hui and Xiao-Bin Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82371508 and 81771439 |
| Jiangsu Provincial Key Research and Development Program |
BE2020661 |
| Suzhou Municipal Health Commission Science Research Program |
GSWS2020095 |
| National Mentorship Training Programme for Young Health Professionals |
Qngg2022027 |
| Suzhou Clinical Key disciplines for Geriatric Psychiatry |
SZXK202116 |
| Suzhou Clinical Medical Center for Mood Disorders |
Szlcyxzx202109 |
| Suzhou Key Technologies Program |
SKY2021063 |
| Suzhou Municipal Science and Technology Bureau Program |
SKJY2021142, SKJY2021143, SKY2023227 |
| Suzhou Municipal Science and Technology Bureau Program |
SKY2022064 and SKYD2023159 |
| Suzhou Key Disease Diagnosis and Treatment Program |
LCZX202218 |
|
| Corresponding Author |
Xiao-Bin Zhang, MD, PhD, Chief Physician, Department of Psychiatry, Suzhou Psychiatric Hospital, Institute of Mental Health, The Affiliated Guangji Hospital of Soochow University, No. 11 Guangqian Road, Suzhou 215137, Jiangsu Province, China. zhangxiaobim@163.com |
| Key Words |
Early-onset schizophrenia; Interleukin 6; Negative symptoms; Avolition; Asociality |
| Core Tip |
In this study, we focus on the negative symptoms and inflammatory levels in the chronic stage of early-onset schizophrenia. Patients' clinical symptoms were assessed by the Positive and Negative Syndrome Scale, and the level of inflammation was assessed by serum interleukin-6 (IL-6) Levels. Our study found that patients with early-onset schizophrenia may have more severe negative symptoms than those with adult-onset schizophrenia during the chronic phase of the illness. IL-6 signaling may regulate negative symptoms and its avolition/asociality subsymptoms among the early-onset chronic schizophrenic patients. |
| Publish Date |
2024-06-19 12:40 |
| Citation |
<p>Chen P, Yang HD, Wang JJ, Zhu ZH, Zhao HM, Yin XY, Cai Y, Zhu HL, Fu JL, Zhang XZ, Sun WX, Hui L, Zhang XB. Association of serum interleukin-6 with negative symptoms in stable early-onset schizophrenia. <i>World J Psychiatry</i> 2024; 14(6): 794-803</p> |
| URL |
https://www.wjgnet.com/2220-3206/full/v14/i6/794.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v14.i6.794 |
