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10/30/2024 11:04:17 AM | Browse: 12 | Download: 36
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Received |
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2024-03-12 13:50 |
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Peer-Review Started |
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2024-03-12 13:50 |
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To Make the First Decision |
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Return for Revision |
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2024-05-24 06:40 |
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Revised |
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2024-06-06 16:44 |
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Second Decision |
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2024-07-02 02:47 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-07-02 10:16 |
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Articles in Press |
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2024-07-02 10:16 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-09-30 06:36 |
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Publish the Manuscript Online |
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2024-10-30 10:50 |
ISSN |
2219-2808 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https: //creativecommons.org/Licenses/by-nc/4.0/ |
Copyright |
The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Pediatrics |
Manuscript Type |
Case Report |
Article Title |
Diazoxide toxicity in congenital hyperinsulinism: A case report
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Roberta Pajno, Camilla Visconti, Carmen Bucolo, Maria Pia Guarneri, Paolo Del Barba, Paolo Silvani, Marco Gregnanin and Graziano Barera |
Funding Agency and Grant Number |
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Corresponding Author |
Roberta Pajno, MD, Attending Doctor, Department of Pediatric, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Institute, Via Olgettina 60, Milan 20132, Lombardy, Italy. pajno.roberta@hsr.it |
Key Words |
Diazoxide; Hypoglycemia; Congenital hyperinsulinism; Side effect; Case report |
Core Tip |
Diazoxide can be effective in treating congenital hyperinsulinism, but its use requires diuretic administration and careful surveillance to prevent and promptly diagnose potential life-threatening adverse effects. Although diazoxide cardiopulmonary side effects were previously described in sporadic case reports, the United States Food and Drug Administration (FDA) has clearly listed them as severe adverse events since 2015. Despite this, numerous reports were published after the FDA statement, describing the increasing rate of these diazoxide side effects. Further studies are needed to identify the underlying mechanism and precise predisposing factors. |
Publish Date |
2024-10-30 10:50 |
Citation |
<p>Pajno R, Visconti C, Bucolo C, Guarneri MP, Del Barba P, Silvani P, Gregnanin M, Barera G. Diazoxide toxicity in congenital hyperinsulinism: A case report. <i>World J Clin Pediatr</i> 2024; 13(4): 94156</p> |
URL |
https://www.wjgnet.com/2219-2808/full/v13/i4/94156.htm |
DOI |
https://dx.doi.org/10.5409/wjcp.v13.i4.94156 |
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