Publication Name	World Journal of Gastroenterology
Manuscript ID	94325
Country	India

Received	2024-03-15 13:31
Peer-Review Started	2024-03-15 13:31
To Make the First Decision
Return for Revision	2024-08-01 22:00
Revised	2024-08-14 10:40
Second Decision	2024-08-21 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-08-21 04:56
Articles in Press	2024-08-21 04:56
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-08-22 10:20
Typeset the Manuscript	2024-09-03 07:11
Publish the Manuscript Online	2024-09-10 09:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Sirtuin 1 in regulating the p53/glutathione peroxidase 4/gasdermin D axis in acute liver failure
Manuscript Source	Invited Manuscript
All Author List	Swati Katoch and Vikram Patial
Funding Agency and Grant Number	Funding Agency Grant Number CSIR, India MLP0204
Corresponding Author	Vikram Patial, PhD, Associate Professor, Division of Dietetics and Nutrition Technology, Institute of Himalayan Bioresource Technology, Post Box No. 6, Palampur 176061, Himachal Pradesh, India. vikrampatial@ihbt.res.in
Key Words	Acute liver failure; Ferroptosis; Gasdermin D; Pyroptosis; p53; Silent information regulator sirtuin 1
Core Tip	Ferroptosis and pyroptosis are crucial modes of hepatic cell death in acute liver failure (ALF), and their close association leads to the sudden progression of liver failure. Silent information regulator sirtuin 1 inhibits p53 activity by deacetylation, thereby promoting cell survival. Inhibition of p53 activity affects downstream regulators like Glutathione peroxidase 4 (GPX4) and Gasdermin D (GSDMD). The overexpression of GPX4 and reduced levels of GSDMD protect the cell from pyroptosis and ferroptosis, indicating the close link between these mechanisms in ALF.
Publish Date	2024-09-10 09:27
Citation	<p>Katoch S, Patial V. Sirtuin 1 in regulating the p53/glutathione peroxidase 4/gasdermin D axis in acute liver failure. <i>World J Gastroenterol</i> 2024; 30(34): 3850-3855</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i34/3850.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i34.3850

Full Article (PDF)	WJG-30-3850-with-cover.pdf
Manuscript File	94325_Auto_Edited_010443.docx
Answering Reviewers	94325-answering-reviewers.pdf
Audio Core Tip	94325-audio.mp3
Conflict-of-Interest Disclosure Form	94325-conflict-of-interest-statement.pdf
Copyright License Agreement	94325-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	94325-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	94325-non-native-speakers.pdf
Peer-review Report	94325-peer-reviews.pdf
Scientific Misconduct Check	94325-scientific-misconduct-check.png
Scientific Editor Work List	94325-scientific-editor-work-list.pdf
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CrossCheck Report	94325-crosscheck-report.pdf