Publication Name	World Journal of Gastroenterology
Manuscript ID	94412
Country	China

Received	2024-03-18 14:01
Peer-Review Started	2024-03-18 14:01
To Make the First Decision
Return for Revision	2024-07-28 06:55
Revised	2024-08-10 01:06
Second Decision	2024-08-16 04:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-08-16 08:27
Articles in Press	2024-08-16 08:27
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-08-22 21:15
Typeset the Manuscript	2024-08-26 01:46
Publish the Manuscript Online	2024-09-02 03:59

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	Xing ZY, Zhang CJ, Liu LJ. Targeting both ferroptosis and pyroptosis may represent potential therapies for acute liver failure. World J Gastroenterol 2024; In press
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Targeting both ferroptosis and pyroptosis may represent potential therapies for acute liver failure
Manuscript Source	Invited Manuscript
All Author List	Zhong-Yuan Xing, Chuan-Jie Zhang and Li-Juan Liu
Funding Agency and Grant Number	Funding Agency Grant Number The Hubei Provincial Natural Science Foundation of China No. 2020CFB656
Corresponding Author	Li-Juan Liu, PhD, Lecturer, Department of Medical Microbiology, School of Basic Medical Sciences, Wuhan University, No. 185 Donghu Road, Wuhan 430071, Hubei Province, China. lijuanliu@whu.edu.cn
Key Words	Acute liver failure; Ferroptosis; Pyroptosis; Crosstalk; Silent information regulator sirtuin 1; P53; Glutathione peroxidase 4; Gasdermin D; Treatment
Core Tip	Acute liver failure (ALF) is a life-threatening disease characterized by uncontrolled death of hepatocytes. Ferroptosis and pyroptosis are two recently discovered types of cell death that can occur simultaneously. However, their roles in ALF remain unclear. The findings show that these two cell death pathways work together to advance ALF and suggest that silent information regulator sirtuin 1 (SIRT1) and its downstream molecules could be potential therapeutics for ALF. Therefore, we will discuss the roles and crosstalk of ferroptosis and pyroptosis in ALF. Activation of SIRT1 and suppression of both cell death pathways may offer new insights into therapeutic targets for ALF.
Publish Date	2024-09-02 03:59
Citation	<p>Xing ZY, Zhang CJ, Liu LJ. Targeting both ferroptosis and pyroptosis may represent potential therapies for acute liver failure. <i>World J Gastroenterol</i> 2024; 30(33): 3791-3798</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i33/3791.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i33.3791

Full Article (PDF)	WJG-30-3791-with-cover.pdf
Manuscript File	94412_Auto_Edited_011023.docx
Answering Reviewers	94412-answering-reviewers.pdf
Audio Core Tip	94412-audio.mp3
Conflict-of-Interest Disclosure Form	94412-conflict-of-interest-statement.pdf
Copyright License Agreement	94412-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	94412-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	94412-non-native-speakers.pdf
Peer-review Report	94412-peer-reviews.pdf
Scientific Misconduct Check	94412-scientific-misconduct-check.png
Scientific Editor Work List	94412-scientific-editor-work-list.pdf
CrossCheck Report	94412-crosscheck-report.pdf