Publication Name	World Journal of Gastroenterology
Manuscript ID	94441
Country	United States

Received	2024-03-18 19:20
Peer-Review Started	2024-03-18 19:20
To Make the First Decision
Return for Revision	2024-05-24 03:59
Revised	2024-06-04 03:59
Second Decision	2024-06-24 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-06-24 06:26
Articles in Press	2024-06-24 06:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-06-28 14:55
Publish the Manuscript Online	2024-07-09 14:00

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Digesting gluten with oral endopeptidases to improve the management of celiac disease
Manuscript Source	Invited Manuscript
All Author List	Katelin Durham and Mirac Nedim Ince
Funding Agency and Grant Number	Funding Agency Grant Number VA Merit Award 2I01BX002906-05
Corresponding Author	Mirac Nedim Ince, MD, Associate Professor, Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Iowa, Carver College of Medicine, 4546 JCP, 200 Hawkins Drive, Iowa City, IA 52242, United States. m-nedim-ince@uiowa.edu
Key Words	Celiac disease; Gluten-free diet; Endopeptidase; Villous atrophy; Aspergillus niger; Adjunct therapy
Core Tip	Patients with celiac disease may still be exposed to gluten despite earnest attempts at adhering to a strict gluten-free diet. Gluten-digesting endopeptidases have emerged as an adjunct therapy for celiac disease. Such endopeptidases digest gluten within the gut to prevent its uptake by antigen presenting cells which initiate small bowel inflammation and villous atrophy. The prolyl endopeptidase derived from Aspergillus niger has shown potential to reduce inadvertent dietary gluten exposure and improve patients’ quality of life.
Publish Date	2024-07-09 14:00
Citation	<p>Durham K, Ince MN. Digesting gluten with oral endopeptidases to improve the management of celiac disease. <i>World J Gastroenterol</i> 2024; 30(26): 3201-3205</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i26/3201.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i26.3201

Full Article (PDF)	WJG-30-3201-with-cover.pdf
Manuscript File	94441_Auto_Edited-YJP.docx
Answering Reviewers	94441-answering-reviewers.pdf
Audio Core Tip	94441-audio.mp3
Conflict-of-Interest Disclosure Form	94441-conflict-of-interest-statement.pdf
Copyright License Agreement	94441-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	94441-foundation-statement.pdf
Peer-review Report	94441-peer-reviews.pdf
Scientific Misconduct Check	94441-scientific-misconduct-check.png
Scientific Editor Work List	94441-scientific-editor-work-list.pdf
CrossCheck Report	94441-crosscheck-report.pdf