Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	94556
Country	United States

Received	2024-03-20 07:45
Peer-Review Started	2024-03-20 07:45
To Make the First Decision
Return for Revision	2024-05-01 20:17
Revised	2024-05-14 23:30
Second Decision	2024-06-11 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-06-11 07:34
Articles in Press	2024-06-11 07:34
Publication Fee Transferred	2024-07-02 23:53
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-07-09 06:55
Publish the Manuscript Online	2024-08-08 04:58

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Serum ferritin and the risk of early-onset colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Adam L Urback, Kylee Martens, Hannah Stowe McMurry, Emerson Y Chen, Caitlin Citti, Anil Sharma, Adel Kardosh and Joseph J Shatzel
Funding Agency and Grant Number	Funding Agency Grant Number National Heart, Lung, and Blood Institute/National Institutes of Health R01HL151367
Corresponding Author	Adam L Urback, BSc, MD, MSc, Doctor, Doctor, Division of Internal Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United States. urback@ohsu.edu
Key Words	Early-onset; Young-onset; Colorectal cancer; Age; Ferritin; Iron deficiency
Core Tip	This is a retrospective study that compares serum ferritin between patients with early-onset colorectal cancer (EO-CRC) and healthy controls (HCs), and examines the association of serum ferritin in EO-CRC with patient- and disease-specific characteristics. We found a higher proportion of individuals with EO-CRC with serum ferritin < 20 ng/mL compared to HCs. Lower serum ferritin in patients with EO-CRC was associated with an earlier stage of disease and a younger age among females. These findings suggest that serum ferritin may be a useful marker in patients with localized disease, emphasizing the importance of early and appropriate gastrointestinal screening in patients found to have iron deficiency.
Publish Date	2024-08-08 04:58
Citation	<p>Urback AL, Martens K, McMurry HS, Chen EY, Citti C, Sharma A, Kardosh A, Shatzel JJ. Serum ferritin and the risk of early-onset colorectal cancer. <i>World J Gastrointest Oncol</i> 2024; 16(8): 3496-3506</p>
URL	https://www.wjgnet.com/1948-5204/full/v16/i8/3496.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i8.3496

Full Article (PDF)	WJGO-16-3496-with-cover.pdf
Manuscript File	94556_Auto_Edited-YJP.docx
Answering Reviewers	94556-answering-reviewers.pdf
Audio Core Tip	94556-audio.m4a
Biostatistics Review Certificate	94556-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	94556-conflict-of-interest-statement.pdf
Copyright License Agreement	94556-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	94556-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	94556-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	94556-institutional-review-board-statement.pdf
Supplementary Material	94556-supplementary-material.pdf
Peer-review Report	94556-peer-reviews.pdf
Scientific Misconduct Check	94556-scientific-misconduct-check.png
Scientific Editor Work List	94556-scientific-editor-work-list.pdf
CrossCheck Report	94556-crosscheck-report.pdf