10/14/2024 9:11:17 AM | Browse: 131 | Download: 269
| Publication Name | World Journal of Clinical Oncology |
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| Manuscript ID | 94739 |
| Country | China |
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| ISSN | 2218-4333 (online) |
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| Open Access | This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright | The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 |
| Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 |
| Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website | http://www.wjgnet.com |
| Category | Computer Science, Information Systems | ||||||||
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| Manuscript Type | Basic Study | ||||||||
| Article Title | Potential regulatory mechanism and clinical significance of synaptotagmin binding cytoplasmic RNA interacting protein in colorectal cancer | ||||||||
| Manuscript Source | Unsolicited Manuscript | ||||||||
| All Author List | Hui Li, He-Qing Huang, Zhi-Guang Huang, Rong-Quan He, Ye-Ying Fang, Rui Song, Jia-Yuan Luo, Da-Tong Zeng, Kai Qin, Dan-Ming Wei and Gang Chen | ||||||||
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| Corresponding Author | Gang Chen, PhD, Professor, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, No. 22 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. chengang@gxmu.edu.cn | ||||||||
| Key Words | Immune microenvironment; Cell mitosis; Radiotherapy; Colorectal cancer; Synaptotagmin binding cytoplasmic RNA interacting protein | ||||||||
| Core Tip | Synaptotagmin binding cytoplasmic RNA interacting protein (SYNCRIP) is regulated by enhancers and POLR2A and highly expressed in colorectal cancer (CRC). Highly expressed SYNCRIP can reduce CD8+ T cells and accelerate CRC cell division by exerting its epigenetic regulatory effects. These CRC cells are sensitive to radiation therapy. Finally, SYNCRIP is expected to become a biomarker in CRC patients. | ||||||||
| Publish Date | 2024-10-14 07:12 | ||||||||
| Citation | <p>Li H, Huang HQ, Huang ZG, He RQ, Fang YY, Song R, Luo JY, Zeng DT, Qin K, Wei DM, Chen G. Potential regulatory mechanism and clinical significance of synaptotagmin binding cytoplasmic RNA interacting protein in colorectal cancer. <i>World J Clin Oncol</i> 2024; 15(11): 1412-1427</p> | ||||||||
| URL | https://www.wjgnet.com/2218-4333/full/v15/i11/1412.htm | ||||||||
| DOI | https://dx.doi.org/10.5306/wjco.v15.i11.1412 |
| Full Article (PDF) | WJCO-15-1412-with-cover.pdf |
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| Manuscript File | 94739_Auto_Edited_020247.docx |
| Answering Reviewers | 94739-answering-reviewers.pdf |
| Audio Core Tip | 94739-audio.mp3 |
| Biostatistics Review Certificate | 94739-biostatistics-statement.pdf |
| Conflict-of-Interest Disclosure Form | 94739-conflict-of-interest-statement.pdf |
| Copyright License Agreement | 94739-copyright-assignment.pdf |
| Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) | 94739-foundation-statement.pdf |
| Institutional Review Board Approval Form or Document | 94739-institutional-review-board-statement.pdf |
| Non-Native Speakers of English Editing Certificate | 94739-non-native-speakers.pdf |
| Supplementary Material | 94739-supplementary-material.pdf |
| Peer-review Report | 94739-peer-reviews.pdf |
| Scientific Misconduct Check | 94739-scientific-misconduct-check.png |
| Scientific Editor Work List | 94739-scientific-editor-work-list.pdf |
| CrossCheck Report | 94739-crosscheck-report.pdf |