BPG is committed to discovery and dissemination of knowledge
Featured Articles
12/30/2024 10:50:49 AM | Browse: 376 | Download: 1181
 |
Received |
|
2024-03-26 16:05 |
|
Peer-Review Started |
|
2024-03-26 16:05 |
|
First Decision by Editorial Office Director |
|
2024-08-28 04:30 |
|
Return for Revision |
|
2024-08-28 04:30 |
|
Revised |
|
2024-09-10 09:33 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2024-11-12 08:31 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2024-11-21 10:05 |
|
Articles in Press |
|
2024-11-21 10:05 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2024-12-20 09:00 |
|
Publish the Manuscript Online |
|
2024-12-30 09:47 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Effect of SPTLC1 on Type 2 diabetes mellitus
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bo Yi, Yan Bao and Zhong-Yuan Wen |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Bo Yi, MD, PhD, Department of Endocrinology, Renmin Hospital of Wuhan University, No. 238 Jiefang Road, Wuchang District, Wuhan 430060, Hubei Province, China. 1227yb@whu.edu.cn |
| Key Words |
Apoptosis; Diabetic peripheral neuropathy; Gene mutation; Inflammation; SPTLC1; Type 2 diabetes mellitus |
| Core Tip |
The single gene defects of type 2 diabetes mellitus (T2DM) with strong family history is not clear yet. We identified Serine Palmitoyltransferase Long Chain Base Subunit 1 (SPTLC1) p.G371R mutation as the likely pathogenic mutation from an adult-onset T2DM patients with strong family history. We also found that this mutation induced the expression of tumor necrosis factor-α and the percent of apoptosis in HEK 293T cells. Moreover, data from AMP T2D knowledge showed a positive correlation between rare variant gene-level associations for SPTLC1 and the risk of T2M. This study provides a novel perspective to understand the pathology of T2DM. |
| Publish Date |
2024-12-30 09:47 |
| Citation |
Yi B, Bao Y, Wen ZY. Effect of SPTLC1 on Type 2 diabetes mellitus. World J Diabetes 2025; 16(2): 94861
|
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i2/94861.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i2.94861 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
