Publication Name	World Journal of Diabetes
Manuscript ID	94861
Country	China

Received	2024-03-26 16:05
Peer-Review Started	2024-03-26 16:05
To Make the First Decision
Return for Revision	2024-08-28 04:30
Revised	2024-09-10 09:33
Second Decision	2024-11-12 08:31
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-11-21 10:05
Articles in Press	2024-11-21 10:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-12-20 09:00
Publish the Manuscript Online	2024-12-30 09:47

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Effect of SPTLC1 on Type 2 diabetes mellitus
Manuscript Source	Unsolicited Manuscript
All Author List	Bo Yi, Yan Bao and Zhong-Yuan Wen
Funding Agency and Grant Number
Corresponding Author	Bo Yi, MD, PhD, Department of Endocrinology, Renmin Hospital of Wuhan University, No. 238 Jiefang Road, Wuchang District, Wuhan 430060, Hubei Province, China. 1227yb@whu.edu.cn
Key Words	Apoptosis; Diabetic peripheral neuropathy; Gene mutation; Inflammation; SPTLC1; Type 2 diabetes mellitus
Core Tip	The single gene defects of type 2 diabetes mellitus (T2DM) with strong family history is not clear yet. We identified Serine Palmitoyltransferase Long Chain Base Subunit 1 (SPTLC1) p.G371R mutation as the likely pathogenic mutation from an adult-onset T2DM patients with strong family history. We also found that this mutation induced the expression of tumor necrosis factor-α and the percent of apoptosis in HEK 293T cells. Moreover, data from AMP T2D knowledge showed a positive correlation between rare variant gene-level associations for SPTLC1 and the risk of T2M. This study provides a novel perspective to understand the pathology of T2DM.
Publish Date	2024-12-30 09:47
Citation	<p>Yi B, Bao Y, Wen ZY. Effect of SPTLC1 on Type 2 diabetes mellitus. <i>World J Diabetes</i> 2025; 16(2): 94861</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i2/94861.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i2.94861

Full Article (PDF)	WJD-16-94861-with-cover.pdf
Manuscript File	94861_Auto_Edited_004608.docx
Answering Reviewers	94861-answering-reviewers.pdf
Audio Core Tip	94861-audio.m4a
Biostatistics Review Certificate	94861-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	94861-conflict-of-interest-statement.pdf
Copyright License Agreement	94861-copyright-assignment.pdf
Institutional Review Board Approval Form or Document	94861-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	94861-non-native-speakers.pdf
Supplementary Material	94861-supplementary-material.pdf
Peer-review Report	94861-peer-reviews.pdf
Journal Editor-in-Chief Review Report	94861-journal-editor-in-chief.pdf
Scientific Misconduct Check	94861-scientific-misconduct-check.png
Scientific Editor Work List	94861-scientific-editor-work-list.pdf
CrossCheck Report	94861-crosscheck-report.png
CrossCheck Report	94861-crosscheck-report.pdf