Publication Name	World Journal of Cardiology
Manuscript ID	94896
Country	Romania

Received	2024-03-27 11:32
Peer-Review Started	2024-03-27 11:32
To Make the First Decision
Return for Revision	2024-08-15 05:48
Revised	2024-08-28 19:39
Second Decision	2024-09-18 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-19 11:01
Articles in Press	2024-09-19 11:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-09-25 06:54
Publish the Manuscript Online	2024-10-17 14:39

ISSN	1949-8462 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Observational Study
Article Title	Metabolic dysfunction-associated steatotic liver disease-associated fibrosis and cardiac dysfunction in patients with type 2 diabetes
Manuscript Source	Invited Manuscript
All Author List	Simona Cernea, Danusia Onișor, Andrada Larisa Roiban, Theodora Benedek and Nora Rat
Funding Agency and Grant Number	Funding Agency Grant Number the University of Medicine, Pharmacy, Science and Technology “George Emil Palade” of Târgu Mureș Research Grant 10126/5/17.12.2020
Corresponding Author	Simona Cernea, MD, PhD, Professor, Department M3/Internal Medicine I, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 38 Gheorghe Marinescu st., Târgu Mureş 540142, Romania. simonacernea@yahoo.com
Key Words	Metabolic dysfunction-associated steatotic liver disease; Type 2 diabetes mellitus; Liver fibrosis; Cardiac dysfunction; Sex-hormone binding protein
Core Tip	Metabolic dysfunction-associated steatotic liver disease (MASLD) is frequently associated with type 2 diabetes mellitus (T2DM), and both conditions are important risk factors for cardiovascular disease. However, the nature of the cardio-liver interaction, particularly in patients with T2DM, is not completely elucidated. In this study we found that T2DM patients with MASLD-associated fibrosis, quantified by accessible scores (Fibrosis-4 and Non-alcoholic fatty liver disease-fibrosis score), present markers of systolic and diastolic dysfunction, as well as cardiac hypertrophy, particularly increased left atrial diameter. The left ventricular mass index and left atrial dimension also correlated negatively with serum concentrations of sex-hormone binding protein, which may serve as a valuable prognostic biomarker. Mechanistic studies that explain the correlations between liver fibrosis and cardiac remodeling in MASLD patients, both with and without T2DM are greatly needed.
Publish Date	2024-10-17 14:39
Citation	<p>Cernea S, Onișor D, Roiban AL, Benedek T, Rat N. Metabolic dysfunction-associated steatotic liver disease-associated fibrosis and cardiac dysfunction in patients with type 2 diabetes. <i>World J Cardiol</i> 2024; 16(10): 580-594</p>
URL	https://www.wjgnet.com/1949-8462/full/v16/i10/580.htm
DOI	https://dx.doi.org/10.4330/wjc.v16.i10.580

Full Article (PDF)	WJC-16-580-with-cover.pdf
STROBE Statement	94896-STROBE-statement.pdf
Manuscript File	94896_Auto_Edited_022118.docx
Answering Reviewers	94896-answering-reviewers.pdf
Audio Core Tip	94896-audio.m4a
Biostatistics Review Certificate	94896-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	94896-conflict-of-interest-statement.pdf
Copyright License Agreement	94896-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	94896-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	94896-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	94896-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	94896-non-native-speakers.pdf
Peer-review Report	94896-peer-reviews.pdf
Scientific Misconduct Check	94896-scientific-misconduct-check.png
Scientific Editor Work List	94896-scientific-editor-work-list.pdf
CrossCheck Report	94896-crosscheck-report.pdf
CrossCheck Report	94896-crosscheck-report.png