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9/9/2024 9:48:36 AM | Browse: 141 | Download: 243
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Received |
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2024-03-28 11:07 |
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Peer-Review Started |
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2024-03-28 11:07 |
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To Make the First Decision |
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Return for Revision |
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2024-05-01 19:38 |
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Revised |
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2024-06-03 16:50 |
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Second Decision |
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2024-07-08 02:41 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-07-08 07:51 |
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Articles in Press |
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2024-07-08 07:51 |
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Publication Fee Transferred |
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2024-07-17 11:41 |
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Edit the Manuscript by Language Editor |
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2024-07-21 23:07 |
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Typeset the Manuscript |
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2024-07-31 05:37 |
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Publish the Manuscript Online |
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2024-09-09 08:41 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Protein tyrosine phosphatase non-receptor II: A possible biomarker of poor prognosis and mediator of immune evasion in hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hui-Yuan Li, Yi-Ming Jing, Xue Shen, Ming-Yue Tang, Hong-Hong Shen, Xin-Wei Li, Zi-Shu Wang and Fang Su |
| Funding Agency and Grant Number |
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| Corresponding Author |
Fang Su, Doctor, MD, PhD, Academic Research, Researcher, Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical University, No. 287 Changhuai Road, Longzihu District, Bengbu 233000, Anhui Province, China. sufang2899@163.com |
| Key Words |
Protein tyrosine phosphatase non-receptor 2; Hepatocellular carcinoma; Immune evasion; Biomarker; Immunotherapy; Prognosis |
| Core Tip |
Our results analysed by immunohistochemical staining, qRT-PCR and immunoblotting in combination with the TCGA database showed that protein tyrosine phosphatase non-receptor 2 (PTPN2) was highly expressed in patients with hepatocellular carcinoma and was associated with poor prognosis. KEGG enrichment analysis then showed that PTPN2 was associated with multiple pathways, including cancer-related pathway, Notch signalling pathway and MAPK signalling pathway. Analysis by constructing a risk model for PTPN2 revealed that immune escape was significantly enhanced in the high-risk group compared with the low-risk group.In this study, PTPN2 was investigated from multiple biological perspectives, and was found to serve as a biomarker of poor prognosis in hepatocellular carcinoma and to mediate immune escape. |
| Publish Date |
2024-09-09 08:41 |
| Citation |
<p>Li HY, Jing YM, Shen X, Tang MY, Shen HH, Li XW, Wang ZS, Su F. Protein tyrosine phosphatase non-receptor II: A possible biomarker of poor prognosis and mediator of immune evasion in hepatocellular carcinoma. <i>World J Gastrointest Oncol</i> 2024; 16(9): 3913-3931</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i9/3913.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i9.3913 |
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