Publication Name	World Journal of Gastroenterology
Manuscript ID	94983
Country	Italy

Received	2024-03-29 07:02
Peer-Review Started	2024-03-29 07:02
To Make the First Decision
Return for Revision	2024-05-01 04:43
Revised	2024-05-10 17:41
Second Decision	2024-05-20 02:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-05-20 05:07
Articles in Press	2024-05-20 05:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-05-30 19:02
Publish the Manuscript Online	2024-06-06 05:43

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	New challenges in hepatocellular carcinoma: A role for PIWI-interacting RNAs?
Manuscript Source	Invited Manuscript
All Author List	Domenico Tierno, Gabriele Grassi and Bruna Scaggiante
Funding Agency and Grant Number
Corresponding Author	Bruna Scaggiante, PhD, N/A, Department of Life Sciences, University of Trieste, Via Valerio 28, Trieste 34127, Italy. bscaggiante@units.it
Key Words	Biomarker; Hepatocellular carcinoma; Liquid biopsy; Non-coding RNA; PIWI-interacting RNA; Next-generation sequencing
Core Tip	Hepatocellular carcinoma (HCC) is a worldwide clinical problem. Over the past decade, several papers have suggested that specific PIWI-interacting RNAs (piRNAs) may be useful as efficient HCC biomarkers at both tissue and serum levels. Interestingly, the piRNA expression profile changes dynamically over the course of the pathological stage from liver fibrosis to HCC development and progression. Knowledge of piRNAs may improve our understanding of HCC and open new clinical perspectives.
Publish Date	2024-06-06 05:43
Citation	<p>Tierno D, Grassi G, Scaggiante B. New challenges in hepatocellular carcinoma: A role for PIWI-interacting RNAs? <i>World J Gastroenterol</i> 2024; 30(22): 2843-2848</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i22/2843.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i22.2843

Full Article (PDF)	WJG-30-2843-with-cover.pdf
Manuscript File	94983_Auto_Edited-YJP.docx
Answering Reviewers	94983-answering-reviewers.pdf
Audio Core Tip	94983-audio.mp3
Conflict-of-Interest Disclosure Form	94983-conflict-of-interest-statement.pdf
Copyright License Agreement	94983-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	94983-non-native-speakers.pdf
Peer-review Report	94983-peer-reviews.pdf
Scientific Misconduct Check	94983-scientific-misconduct-check.png
Scientific Misconduct Check	94983-scientific-misconduct-check.png
Scientific Editor Work List	94983-scientific-editor-work-list.pdf
CrossCheck Report	94983-crosscheck-report.pdf