Publication Name	World Journal of Stem Cells
Manuscript ID	95163
Country	Saudi Arabia

Received	2024-04-02 22:26
Peer-Review Started	2024-04-02 22:26
To Make the First Decision
Return for Revision	2024-05-02 20:33
Revised	2024-05-04 17:12
Second Decision	2024-05-20 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-05-20 06:49
Articles in Press	2024-05-20 06:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-05-23 11:55
Publish the Manuscript Online	2024-06-25 10:11

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell & Tissue Engineering
Manuscript Type	Editorial
Article Title	Priming mesenchymal stem cells to develop “super stem cells”
Manuscript Source	Invited Manuscript
All Author List	Khawaja Husnain Haider
Funding Agency and Grant Number
Corresponding Author	Khawaja Husnain Haider, BPharm, BSc, PhD, Chairman, Full Professor, Professor, Department of Basic Sciences, Sulaiman AlRajhi University, AlMadina Road, AlQaseem 52736, Saudi Arabia. kh.haider@sr.edu.sa
Key Words	Cell survival; Cell therapy; Preconditioning; Pre-treatment; Stem cells; Super stem cells
Core Tip	Stem cell pre-treatment is a promising approach for accentuating their stemness and reparability and improving their resistance to apoptosis in the harsh microenvironment of the injured tissue. The current stem cell pre-treatment protocols allow for enhancing their therapeutic efficacy to surmount the limitations of mesenchymal stem cells (MSCs), i.e., mobility, survival, engraftment, and paracrine activity. Besides a novel sub-cellular preconditioning strategy, the combinative preconditioning approach exposing the cells to a proinflammatory milieu under hypoxia improves MSCs’ immunoregulatory potential. Refining a combinatorial pre-treatment protocol using a well-defined mechanistic understanding may allow the exploitation of the full benefits of the pre-treated “super MSCs” for enhanced stemness, functionality, and reparability, including immunosuppressive and immunomodulatory properties.
Publish Date	2024-06-25 10:11
Citation	<p>Haider KH. Priming mesenchymal stem cells to develop “super stem cells”. <i>World J Stem Cells</i> 2024; 16(6): 623-640</p>
URL	https://www.wjgnet.com/1948-0210/full/v16/i6/623.htm
DOI	https://dx.doi.org/10.4252/wjsc.v16.i6.623

Full Article (PDF)	WJSC-16-623-with-cover.pdf
Manuscript File	95163_Auto_Edited-YJP.docx
Answering Reviewers	95163-answering-reviewers.pdf
Audio Core Tip	95163-audio.mp3
Conflict-of-Interest Disclosure Form	95163-conflict-of-interest-statement.pdf
Copyright License Agreement	95163-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	95163-non-native-speakers.pdf
Peer-review Report	95163-peer-reviews.pdf
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Scientific Misconduct Check	95163-scientific-misconduct-check.png
Scientific Editor Work List	95163-scientific-editor-work-list.pdf
CrossCheck Report	95163-crosscheck-report.pdf