Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	95320
Country	Bulgaria

Received	2024-04-08 00:01
Peer-Review Started	2024-04-08 00:01
To Make the First Decision
Return for Revision	2024-05-03 04:29
Revised	2024-05-12 18:28
Second Decision	2024-07-08 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-07-08 06:20
Articles in Press	2024-07-08 06:20
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-07-16 19:12
Typeset the Manuscript	2024-08-02 03:41
Publish the Manuscript Online	2024-09-28 04:34

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Urgent need for prognostic markers for hepatocellular carcinoma in the light of genomic instability and non-coding RNA signatures
Manuscript Source	Invited Manuscript
All Author List	Tsvetelina Velikova and Milena Gulinac
Funding Agency and Grant Number	Funding Agency Grant Number The European Union-Next Generation EU, through the National Recovery and Resilience Plan of the Republic of Bulgaria BG-RRP-2.004-0008
Corresponding Author	Milena Gulinac, MD, PhD, Academic Research, General and Clinical Pathology, Medical University of Plovdiv, 15A Vassil Aprilov Blvd, Plovdiv 4002, Bulgaria. mgulinac@hotmail.com
Key Words	Genomic instability; Long non-coding RNA; RNA signatures; Hepatocellular carcinoma; Liver cancer; Prognosis; Prognostic markers; Diagnosis; Precision medicine
Core Tip	Despite challenges in diagnosing and treating hepatocellular carcinoma (HCC), identifying suitable prognostic factors is crucial. Duan et al proposed a novel approach using long non-coding RNAs (LncRNAs) to quantify genomic instability (GI) in HCC. Their study demonstrated that the GI-derived LncRNA signature is an independent prognostic factor, outperforming TP53 mutation status alone with an area under the curve of 0.773. These findings underscore the importance of exploring genetic markers for predicting HCC prognosis, aiding in identifying therapeutic targets and improving diagnostic and treatment strategies to alleviate the global burden of this disease.
Publish Date	2024-09-28 04:34
Citation	<p>Velikova T, Gulinac M. Urgent need for prognostic markers for hepatocellular carcinoma in the light of genomic instability and non-coding RNA signatures. <i>World J Gastrointest Surg</i> 2024; 16(10): 3087-3090</p>
URL	https://www.wjgnet.com/1948-9366/full/v16/i10/3087.htm
DOI	https://dx.doi.org/10.4240/wjgs.v16.i10.3087

Full Article (PDF)	WJGS-16-3087-with-cover.pdf
Manuscript File	95320_Auto_Edited_014315.docx
Answering Reviewers	95320-answering-reviewers.pdf
Audio Core Tip	95320-audio.mp3
Conflict-of-Interest Disclosure Form	95320-conflict-of-interest-statement.pdf
Copyright License Agreement	95320-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	95320-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	95320-non-native-speakers.pdf
Peer-review Report	95320-peer-reviews.pdf
Scientific Misconduct Check	95320-scientific-misconduct-check.png
Scientific Editor Work List	95320-scientific-editor-work-list.pdf
CrossCheck Report	95320-crosscheck-report.pdf