Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	95698
Country	China

Received	2024-04-16 09:36
Peer-Review Started	2024-04-16 09:36
To Make the First Decision
Return for Revision	2024-08-17 19:47
Revised	2024-09-09 16:17
Second Decision	2024-10-08 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-08 07:45
Articles in Press	2024-10-08 07:45
Publication Fee Transferred	2024-10-11 03:17
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-10-21 07:23
Publish the Manuscript Online	2024-11-12 12:23

ISSN	1948-5204 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Vitamin D 1,25-Dihydroxyvitamin D₃ reduces lipid accumulation in hepatocytes by inhibiting M1 macrophage polarization
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Jing Luo, Xian-Wen Dong, Hua Ye, Qiao-Su Zhao, Qiu-Bo Zhang, Wen-Ying Guo, Hui-Wei Liu and Feng Xu
Funding Agency and Grant Number
Corresponding Author	Feng Xu, MAMS, Chief Physician, Department of Gastroenterology, Ningbo Medical Center Lihuili Hospital, No. 57 Xingning Road, Ningbo 315000, Zhejiang Province, China. xufeng200468@126.com
Key Words	Non-alcoholic fatty liver disease; Hepatocytes; Macrophages; Polarization; Vitamin D receptor; Peroxisome proliferator activated receptor γ
Core Tip	Supplementation with 1,25-dihydroxy-vitamin D [1,25(OH)2D3] improved hepatic steatosis and lipid metabolism in nonalcoholic fatty liver disease, linked to its capacity to reverse the proinflammatory M1 polarization of hepatic macrophages, partially by regulating the vitamin D receptor-peroxisome proliferator activated receptor γ pathway. The involvement of 1,25(OH)2D3 in inhibiting fatty-acid-induced proinflammatory M1 polarization of macrophages played a direct role in relieving lipid accumulation and metabolism in hepatocytes.
Publish Date	2024-11-12 12:23
Citation	<p>Luo WJ, Dong XW, Ye H, Zhao QS, Zhang QB, Guo WY, Liu HW, Xu F. Vitamin D 1,25-Dihydroxyvitamin D₃ reduces lipid accumulation in hepatocytes by inhibiting M1 macrophage polarization. <i>World J Gastrointest Oncol</i> 2024; 16(12): 4685-4699</p>
URL	https://www.wjgnet.com/1948-5204/full/v16/i12/4685.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i12.4685

Full Article (PDF)	WJGO-16-4685-with-cover.pdf
The ARRIVE Guidelines	95698-The-ARRIVE-Guidelines.pdf
Manuscript File	95698_Auto_Edited_014106.docx
Answering Reviewers	95698-answering-reviewers.pdf
Audio Core Tip	95698-audio.mp3
Biostatistics Review Certificate	95698-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	95698-conflict-of-interest-statement.pdf
Copyright License Agreement	95698-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	95698-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	95698-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	95698-non-native-speakers.pdf
Peer-review Report	95698-peer-reviews.pdf
Scientific Misconduct Check	95698-scientific-misconduct-check.png
Scientific Editor Work List	95698-scientific-editor-work-list.pdf
CrossCheck Report	95698-crosscheck-report.png
CrossCheck Report	95698-crosscheck-report.pdf