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7/9/2024 2:26:32 PM | Browse: 47 | Download: 57
Publication Name World Journal of Gastroenterology
Manuscript ID 96258
Country China
Received
2024-04-30 18:35
Peer-Review Started
2024-04-30 18:35
To Make the First Decision
Return for Revision
2024-05-16 19:23
Revised
2024-05-28 18:48
Second Decision
2024-06-03 02:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2024-06-03 05:58
Articles in Press
2024-06-03 05:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
2024-06-23 14:36
Typeset the Manuscript
2024-06-30 14:43
Publish the Manuscript Online
2024-07-09 14:00
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Loss of monopolar spindle-binding protein 3B expression promotes colorectal cancer malignant behaviors by activation of target of rapamycin kinase/autophagy signaling
Manuscript Source Unsolicited Manuscript
All Author List Juan Sun, Jin-Xiu Zhang, Meng-Shi Li, Meng-Bin Qin, Ruo-Xi Cheng, Qing-Ru Wu, Qiu-Ling Chen, Dan Yang, Cun Liao, Shi-Quan Liu and Jie-An Huang
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81760516
Natural Science Foundation of Guangxi, China 2019GXNSFAA185030
Self-Financed Scientific Research Projects of Guangxi Zhuang Autonomous Region Health and Family Planning Commission, China Z20181003
Guangxi Medical University Youth Science Fund Project, China GXMUYSF202221
Corresponding Author Jie-An Huang, PhD, Chief Physician, Professor, Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxue East Road, Xixiangtang District, Nanning 530007, Guangxi Zhuang Autonomous Region, China. hjagxmu@163.com
Key Words Colorectal cancer; Monopolar spindle-binding protein 3B; Mechanistic target of rapamycin kinase; Autophagy; Prognosis
Core Tip Monopolar spindle-binding protein 3B (MOB3B) functions as a signal transducer and altered MOB3B expression associated with development of human cancers. In our study, we investigated the effects of MOB3B in colorectal cancer (CRC). We found that loss of MOB3B expression promoted CRC development and malignant behaviors, suggesting a potential tumor suppressive role of MOB3B in CRC by inhibition of mechanistic target of rapamycin kinase/autophagy signaling.
Publish Date 2024-07-09 14:00
Citation <p>Sun J, Zhang JX, Li MS, Qin MB, Cheng RX, Wu QR, Chen QL, Yang D, Liao C, Liu SQ, Huang JA. Loss of monopolar spindle-binding protein 3B expression promotes colorectal cancer malignant behaviors by activation of target of rapamycin kinase/autophagy signaling. <i>World J Gastroenterol</i> 2024; 30(26): 3229-3246</p>
URL https://www.wjgnet.com/1007-9327/full/v30/i26/3229.htm
DOI https://dx.doi.org/10.3748/wjg.v30.i26.3229
Full Article (PDF) WJG-30-3229-with-cover.pdf
The ARRIVE Guidelines 96258-The-ARRIVE-Guidelines.pdf
Manuscript File 96258_Auto_Edited-YJP_WangTQ.docx
Answering Reviewers 96258-answering-reviewers.pdf
Audio Core Tip 96258-audio.mp3
Biostatistics Review Certificate 96258-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 96258-conflict-of-interest-statement.pdf
Copyright License Agreement 96258-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 96258-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 96258-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document 96258-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 96258-non-native-speakers.pdf
Peer-review Report 96258-peer-reviews.pdf
Scientific Misconduct Check 96258-scientific-misconduct-check.png
Scientific Editor Work List 96258-scientific-editor-work-list.pdf
CrossCheck Report 96258-crosscheck-report.pdf