| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Loss of monopolar spindle-binding protein 3B expression promotes colorectal cancer invasiveness by activation of target of rapamycin kinase/autophagy signaling
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Juan Sun, Jin-Xiu Zhang, Meng-Shi Li, Meng-Bin Qin, Ruo-Xi Cheng, Qing-Ru Wu, Qiu-Ling Chen, Dan Yang, Cun Liao, Shi-Quan Liu and Jie-An Huang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81760516 |
| Natural Science Foundation of Guangxi, China |
2019GXNSFAA185030 |
| Self-Financed Scientific Research Projects of Guangxi Zhuang Autonomous Region Health and Family Planning Commission, China |
Z20181003 |
| Guangxi Medical University Youth Science Fund Project, China |
GXMUYSF202221 |
|
| Corresponding Author |
Jie-An Huang, PhD, Chief Physician, Professor, Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxue East Road, Xixiangtang District, Nanning 530007, Guangxi Zhuang Autonomous Region, China. hjagxmu@163.com |
| Key Words |
Colorectal cancer; Monopolar spindle-binding protein 3B; Mechanistic target of rapamycin kinase; Autophagy; Prognosis |
| Core Tip |
Monopolar spindle-binding protein 3B (MOB3B) functions as a signal transducer and altered MOB3B expression associated with development of human cancers. In our study, we investigated the effects of MOB3B in colorectal cancer (CRC). We found that loss of MOB3B expression promoted CRC development and malignant behaviors, suggesting a potential tumor suppressive role of MOB3B in CRC by inhibition of mechanistic target of rapamycin kinase/autophagy signaling. |
| Publish Date |
2024-07-09 14:00 |
| Citation |
<p>Sun J, Zhang JX, Li MS, Qin MB, Cheng RX, Wu QR, Chen QL, Yang D, Liao C, Liu SQ, Huang JA. Loss of monopolar spindle-binding protein 3B expression promotes colorectal cancer invasiveness by activation of target of rapamycin kinase/autophagy signaling. <i>World J Gastroenterol</i> 2024; 30(26): 3229-3246</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i26/3229.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i26.3229 |
