| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Adenosine triphosphate-binding pocket inhibitor for mixed lineage kinase domain-like protein attenuated alcoholic liver disease via necroptosis-independent pathway
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Han-Ning Xuan Yuan, Hyun Sung Kim, Gye Ryeol Park, Jae Eun Ryu, Ji Eun Kim, In Young Kang, Hye Young Kim, Seung Min Lee, Ju Hee Oh, Eileen L Yoon and Dae Won Jun |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research Foundation of Korea Grant Funded by the Korea Government |
No. RS-2024-00440477 |
| Korea Institute of Science and Technology Institutional Program |
No. 2E33111-24-042 |
|
| Corresponding Author |
Dae Won Jun, PhD, Department of Internal Medicine, Hanyang University School of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, South Korea. noshin@hanyang.ac.kr |
| Key Words |
RAW 264.7 cell; Cell death; Necroptosis; Mixed lineage kinase domain-like protein; Non-alcoholic fatty liver disease; Mixed lineage kinase domain-like protein adenosine triphosphate binding inhibitor; Alcoholic liver disease |
| Core Tip |
Targeting the adenosine triphosphate-binding pocket of mixed lineage kinase domain-like protein may provide a novel therapeutic strategy for reducing inflammation in alcoholic liver disease, independent of its role in necroptosis, highlighting its potential as a unique target in liver disease management. |
| Publish Date |
2025-01-10 08:40 |
| Citation |
<p>Xuan Yuan HN, Kim HS, Park GR, Ryu JE, Kim JE, Kang IY, Kim HY, Lee SM, Oh JH, Yoon EL, Jun DW. Adenosine triphosphate-binding pocket inhibitor for mixed lineage kinase domain-like protein attenuated alcoholic liver disease via necroptosis-independent pathway. <i>World J Gastroenterol</i> 2025; 31(6): 96782</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i6/96782.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i6.96782 |
