Publication Name	World Journal of Gastroenterology
Manuscript ID	96898
Country	Italy

Received	2024-05-17 11:05
Peer-Review Started	2024-05-17 11:05
To Make the First Decision
Return for Revision	2024-08-21 23:35
Revised	2024-08-23 10:46
Second Decision	2024-09-06 03:03
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-06 06:13
Articles in Press	2024-09-06 06:13
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-09-14 22:54
Typeset the Manuscript	2024-09-19 07:44
Publish the Manuscript Online	2024-09-29 09:24

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Beyond the gluten-free diet: Innovations in celiac disease therapeutics
Manuscript Source	Invited Manuscript
All Author List	Sara Massironi, Marianna Franchina, Alessandra Elvevi and Donatella Barisani
Funding Agency and Grant Number
Corresponding Author	Sara Massironi, MD, PhD, Adjunct Professor, Division of Gastroenterology, Fondazione IRCCS San Gerardo dei Tintori, University of Milano-Bicocca, Via Pergolesi 33, Monza 20900, Italy. sara.massironi@libero.it
Key Words	Celiac disease; Gluten tolerance; Enzymatic degradation; Therapeutic advances; Transglutaminase inhibitors; Tight junction modulators
Core Tip	The landscape of celiac disease treatment is evolving beyond the traditional gluten-free diet due to the challenges of strict adherence to the diet and incomplete resolution of symptoms. This review highlights emerging therapeutic strategies, including gluten sequestration and degradation, gluten tolerance induction, tight junction modulators, transglutaminase inhibitors, lymphocyte trafficking and homing inhibitors. These novel therapies, which target specific molecular and immune signaling pathways, promise to improve patient outcomes and quality of life by reducing dietary restrictions and addressing persistent inflammation and symptoms. Further research and multidisciplinary collaboration are critical to integrate these advances into standard clinical practice.
Publish Date	2024-09-29 09:24
Citation	<p>Massironi S, Franchina M, Elvevi A, Barisani D. Beyond the gluten-free diet: Innovations in celiac disease therapeutics. <i>World J Gastroenterol</i> 2024; 30(38): 4194-4210</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i38/4194.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i38.4194

Full Article (PDF)	WJG-30-4194-with-cover.pdf
Manuscript File	96898_Auto_Edited_005644.docx
Answering Reviewers	96898-answering-reviewers.pdf
Audio Core Tip	96898-audio.m4a
Conflict-of-Interest Disclosure Form	96898-conflict-of-interest-statement.pdf
Copyright License Agreement	96898-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	96898-non-native-speakers.pdf
Peer-review Report	96898-peer-reviews.pdf
Scientific Misconduct Check	96898-scientific-misconduct-check.png
Scientific Editor Work List	96898-scientific-editor-work-list.pdf
CrossCheck Report	96898-crosscheck-report.pdf