Publication Name	World Journal of Diabetes
Manuscript ID	96953
Country	China

Received	2024-05-19 14:41
Peer-Review Started	2024-05-19 14:41
To Make the First Decision
Return for Revision	2024-09-01 22:24
Revised	2024-09-22 00:46
Second Decision	2024-10-16 06:59
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-23 08:52
Articles in Press	2024-10-23 08:52
Publication Fee Transferred	2024-10-28 10:28
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-11-05 08:44
Publish the Manuscript Online	2024-11-18 03:30

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Medicine, General & Internal
Manuscript Type	Case Report
Article Title	Peroxisome proliferator-activated receptor gamma mutation in familial partial lipodystrophy type three: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Chao-Jun Wu, Hao Liu, Li-Juan Tu and Jiong-Yu Hu
Funding Agency and Grant Number
Corresponding Author	Jiong-Yu Hu, MD, Associate Professor, Department of Endocrinology, Rare Disease Center, The First Affiliated Hospital of Army Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing 400038, China. jiongyu-hu@tmmu.edu.cn
Key Words	Familial partial lipodystrophy; Peroxisome proliferator-activated receptor gamma; Tyr151Cys; Phenotypic heterogeneity; Case report
Core Tip	This study reports a rare peroxisome proliferator-activated receptor gamma (PPARG) mutation (Y151C) in a 31-year-old woman with familial partial lipodystrophy type 3 (FPLD3), characterized by adipose tissue loss and metabolic complications. The mutation was identified in the PPARG DNA-binding domain. Pioglitazone, a PPARG agonist, effectively improved the patient’s glycemic and blood pressure control. This highlights the importance of genetic testing in FPLD3 diagnosis and the potential of PPARG agonists in managing metabolic complications.
Publish Date	2024-11-18 03:30
Citation	<p>Wu CJ, Liu H, Tu LJ, Hu JY. Peroxisome proliferator-activated receptor gamma mutation in familial partial lipodystrophy type three: A case report and review of literature. <i>World J Diabetes</i> 2024; 15(12): 2360-2369</p>
URL	https://www.wjgnet.com/1948-9358/full/v15/i12/2360.htm
DOI	https://dx.doi.org/10.4239/wjd.v15.i12.2360

Full Article (PDF)	WJD-15-2360-with-cover.pdf
CARE Checklist–2016	96953-CARE-Checklist-2016.pdf
Manuscript File	96953_Auto_Edited_020042.docx
Answering Reviewers	96953-answering-reviewers.pdf
Audio Core Tip	96953-audio.mp3
Conflict-of-Interest Disclosure Form	96953-conflict-of-interest-statement.pdf
Copyright License Agreement	96953-copyright-assignment.pdf
Signed Consent for Treatment Form(s) or Document(s)	96953-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate	96953-non-native-speakers.pdf
Peer-review Report	96953-peer-reviews.pdf
Journal Editor-in-Chief Review Report	96953-journal-editor-in-chief.pdf
Scientific Misconduct Check	96953-scientific-misconduct-check.png
Scientific Editor Work List	96953-scientific-editor-work-list.pdf
CrossCheck Report	96953-crosscheck-report.png
CrossCheck Report	96953-crosscheck-report.pdf