| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Blood cell counts and nonalcoholic fatty liver disease: Evidence from Mendelian randomization analysis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bin Hu, Ai-Hong Wan, Xi-Qiao Xiang, Yuan-Hao Wei, Yi Chen, Zhen Tang, Chang-De Xu, Zi-Wei Zheng, Shao-Ling Yang and Kun Zhao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Shanghai Natural Science Foundation of China |
23ZR1447800 |
| the Fengxian District Science and Technology Commission Project, China |
20211838 |
|
| Corresponding Author |
Kun Zhao, MD, Doctor, Doctor, Department of Positron Emission Tomography-Computed Tomography Imaging Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, No. 6600 Nanfeng Highway, Shanghai 201499, China. zzleaning@163.com |
| Key Words |
Blood cell counts; Liver enzymes; Nonalcoholic fatty liver disease; Genome-wide association; Mendelian randomization study; Causal relationship |
| Core Tip |
Mendelian randomization analysis revealed a novel evidence for a causal role of genetically predicted blood cell traits in liver injury and nonalcoholic fatty liver disease (NAFLD). The study found that genetically determined increases in hemoglobin concentration (HGB) and hematocrit levels were associated with elevated levels of liver enzymes. In addition, genetic determinants of HGB and reticulocyte ratio are associated with an increased risk of NAFLD. These findings may help in the diagnosis and prevention of NAFLD. |
| Publish Date |
2024-08-21 23:22 |
| Citation |
<p>Hu B, Wan AH, Xiang XQ, Wei YH, Chen Y, Tang Z, Xu CD, Zheng ZW, Yang SL, Zhao K. Blood cell counts and nonalcoholic fatty liver disease: Evidence from Mendelian randomization analysis. <i>World J Hepatol</i> 2024; 16(8): 1145-1155</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v16/i8/1145.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v16.i8.1145 |
