| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Radiology, Nuclear Medicine & Medical Imaging |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Whole-volume histogram analysis of spectral-computed tomography iodine maps characterizes HER2 expression in gastric cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei-Ling Zhang, Jing Sun, Rong-Fang Huang, Yi Zeng, Shu Chen, Xiao-Peng Wang, Jin-Hu Chen, Yun-Bin Chen, Chun-Su Zhu, Zai-Sheng Ye and You-Ping Xiao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Program of Fujian Province |
2021J01430 |
| Joint Funds for the innovation of Science and Technology of Fujian Province |
2021Y9229 |
|
| Corresponding Author |
You-Ping Xiao, MD, Doctor, Department of Radiology, Clinical Oncology School of Fujian Medical University & Fujian Cancer Hospital (Fujian Branch of Fudan University Affiliated Cancer Hospital), No. 420 Fuma Road, Jin'an District, Fuzhou 350014, Fujian Province, China. xyp999@yeah.net |
| Key Words |
Gastric cancer; Spectral computed tomography; Iodine map; Histogram analysis |
| Core Tip |
Anti-HER2 receptor is a critical biomarker in gastric cancer (GC). In this study, a total of 101 GC patients underwent preoperative spectral-computed tomography (sCT) and nineteen parameters were extracted from the iodine maps of sCT by histogram analysis. The relationship between parameters derived from whole volume histogram analysis of sCT and HER-2 status of GC were further investigated. Our present results indicated that parameters derived from sCT, particularly the 99th percentiles, could be utilized as an imaging biomarker in assessing the HER2 overexpression of GC. This founding would help Gastrointestinal Oncologists to develop an effective treatment strategy for patients with GC. |
| Publish Date |
2024-09-29 09:24 |
| Citation |
<p>Zhang WL, Sun J, Huang RF, Zeng Y, Chen S, Wang XP, Chen JH, Chen YB, Zhu CS, Ye ZS, Xiao YP. Whole-volume histogram analysis of spectral-computed tomography iodine maps characterizes HER2 expression in gastric cancer. <i>World J Gastroenterol</i> 2024; 30(38): 4211-4220</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i38/4211.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i38.4211 |
