Publication Name	World Journal of Gastroenterology
Manuscript ID	97011
Country	India

Received	2024-05-20 09:05
Peer-Review Started	2024-05-20 09:06
To Make the First Decision
Return for Revision	2024-07-18 01:04
Revised	2024-07-23 09:00
Second Decision	2024-07-26 02:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-07-26 08:35
Articles in Press	2024-07-26 08:35
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-08-08 13:37
Typeset the Manuscript	2024-08-26 03:47
Publish the Manuscript Online	2024-09-02 03:59

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Editorial
Article Title	Colorectal cancer cell dormancy: An insight into pathways
Manuscript Source	Invited Manuscript
All Author List	Anil Kumar and Lekha Saha
Funding Agency and Grant Number
Corresponding Author	Lekha Saha, Doctor, MBBS, MD, Professor, Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India. lekhsaha@rediffmail.com
Key Words	Colorectal cancer; Colorectal cancer cell dormancy; Cancer cell dormancy; Pathways in colorectal cancer dormancy
Core Tip	Colorectal cancer (CRC) cell dormancy drives therapeutic resistance, recurrence, and metastasis. Key molecular pathways involved in CRC dormancy include Hippo/YAP, NANOG, HIF-1α, Notch, ERK/MAPK, AKT, Wnt, and SMAD. Dysregulation of these pathways promotes dormancy. After re-entering in active tumor state following dormancy, these cancer cells become more aggressive and metastasize quickly. The mechanisms behind CRC dormancy are largely unexplored. This editorial summarizes these pathways and their interactions, highlighting the identification of predictive biomarkers crucial for developing targeted therapies, overcoming drug resistance, and enhancing personalized treatments and patient outcomes.
Publish Date	2024-09-02 03:59
Citation	<p>Kumar A, Saha L. Colorectal cancer cell dormancy: An insight into pathways. <i>World J Gastroenterol</i> 2024; 30(33): 3810-3817</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i33/3810.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i33.3810

Full Article (PDF)	WJG-30-3810-with-cover.pdf
Manuscript File	97011_Auto_Edited_060448.docx
Answering Reviewers	97011-answering-reviewers.pdf
Audio Core Tip	97011-audio.mp3
Conflict-of-Interest Disclosure Form	97011-conflict-of-interest-statement.pdf
Copyright License Agreement	97011-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	97011-non-native-speakers.pdf
Peer-review Report	97011-peer-reviews.pdf
Scientific Misconduct Check	97011-scientific-misconduct-check.png
Scientific Editor Work List	97011-scientific-editor-work-list.pdf
CrossCheck Report	97011-crosscheck-report.pdf