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9/3/2024 10:28:05 AM | Browse: 45 | Download: 18
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Received |
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2024-06-02 17:55 |
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2024-08-15 19:45 |
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2024-08-22 21:47 |
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2024-08-28 02:41 |
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2024-08-28 10:19 |
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2024-08-28 10:19 |
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2024-08-29 07:48 |
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2024-09-03 08:54 |
ISSN |
2150-5349 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Transplantation |
Manuscript Type |
Minireviews |
Article Title |
Downstaging of advanced hepatocellular carcinoma followed by liver transplantation using immune checkpoint inhibitors: Where do we stand?
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Manuscript Source |
Invited Manuscript |
All Author List |
Hirak Pahari, Javid A Peer, Shikhar Tripathi, Suresh K Singhvi and Ushast Dhir |
Funding Agency and Grant Number |
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Corresponding Author |
Hirak Pahari, DNB, MBBS, Surgeon, Department of Liver Transplant and Hepatobiliary Surgery, Sir Ganga Ram Hospital, Old Rajinder Nagar, New Delhi 110060, Delhi, India. hirak.pahari@gmail.com |
Key Words |
Hepatocellular carcinoma; Liver transplant; Downstaging; Atezolizumab; Nivolumab; Immune checkpoint inhibitors |
Core Tip |
The advent of immune checkpoint inhibitors as a downstaging therapy has been followed with great interest since the results of the IMBRAVE study, especially for multifocal hepatocellular carcinoma beyond criteria and certain cases with portal vein tumor thrombosis. Multiple case reports have shown benefit but with a degree of caution. Our review aims to identify the key points and recommendations for the safe usage of these life-saving immunomodulators in the setting of liver transplantation using the current available literature. |
Publish Date |
2024-09-03 08:54 |
Citation |
<p>Pahari H, Peer JA, Tripathi S, Singhvi SK, Dhir U. Downstaging of advanced hepatocellular carcinoma followed by liver transplantation using immune checkpoint inhibitors: Where do we stand? <i>World J Gastrointest Pharmacol Ther</i> 2024; 15(5): 97570</p> |
URL |
https://www.wjgnet.com/2150-5349/full/v15/i5/97570.htm |
DOI |
https://dx.doi.org/10.4292/wjgpt.v15.i5.97570 |
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