Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	97673
Country	China

Received	2024-06-05 03:40
Peer-Review Started	2024-06-05 03:40
To Make the First Decision
Return for Revision	2024-10-10 08:52
Revised	2024-10-30 07:47
Second Decision	2024-12-04 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-04 08:16
Articles in Press	2024-12-04 08:16
Publication Fee Transferred	2024-12-09 06:20
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-12-31 02:58
Publish the Manuscript Online	2025-02-14 10:33

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Transmembrane protein 176B promotes epithelial-mesenchymal transition in colorectal cancer through inflammasome inhibition
Manuscript Source	Unsolicited Manuscript
All Author List	Wei Qian, Chong-Yi Xu, Wei Hong, Zhe-Ming Li and Dao-Gun Xu
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Education Industry-University Co-operation Collaborative Education Project 202102242020
Corresponding Author	Dao-Gun Xu, Department of Proctology, Wenling Hospital of Traditional Chinese Medicine affiliated to Zhejiang Chinese Medical University, No. 21 Mingyuan Road, Taiping Street, Wenling 317500, Zhejiang Province, China. 13906569665@163.com
Key Words	Transmembrane protein 176B; Epithelial-mesenchymal transition; Colorectal cancer; Pyrin domain containing 3 inflammasome; Natural killer cell
Core Tip	Silencing Transmembrane protein 176B (TMEM176B) inhibited tumor metastasis, proliferation, and epithelial-mesenchymal transition in colorectal cancer (CRC) in situ, in mice co-cultured with natural killer (NK) cells, while activating apoptosis, NLRP3 inflammasome, and NK cell function. The interference of NLRP3 reversed these effects by modulating key proteins such as phosphorylated nuclear factor kappa B subunit 1 p65, matrix metallopeptidase 9, and transforming growth factor-β. This study highlights the critical role of TMEM176B/NLRP3 in CRC management, providing a basis for targeting this axis as a novel therapeutic approach to manage CRC progression and metastasis.
Publish Date	2025-02-14 10:33
Citation	<p>Qian W, Xu CY, Hong W, Li ZM, Xu DG. Transmembrane protein 176B promotes epithelial-mesenchymal transition in colorectal cancer through inflammasome inhibition. <i>World J Gastrointest Oncol</i> 2025; 17(3): 97673</p>
URL	https://www.wjgnet.com/1948-5204/full/v17/i3/97673.htm
DOI	https://dx.doi.org/10.4251/wjgo.v17.i3.97673

Full Article (PDF)	WJGO-17-97673-with-cover.pdf
The ARRIVE Guidelines	97673-The-ARRIVE-Guidelines.pdf
Manuscript File	97673_Auto_Edited_013905.docx
Answering Reviewers	97673-answering-reviewers.pdf
Audio Core Tip	97673-audio.mp3
Biostatistics Review Certificate	97673-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	97673-conflict-of-interest-statement.pdf
Copyright License Agreement	97673-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	97673-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	97673-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	97673-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	97673-non-native-speakers.pdf
Peer-review Report	97673-peer-reviews.pdf
Scientific Misconduct Check	97673-scientific-misconduct-check.png
Scientific Editor Work List	97673-scientific-editor-work-list.pdf
CrossCheck Report	97673-crosscheck-report.pdf