Publication Name	World Journal of Pharmacology
Manuscript ID	97723
Country	South Africa

Received	2024-06-13 20:38
Peer-Review Started	2024-06-13 20:38
To Make the First Decision
Return for Revision	2024-09-19 22:14
Revised	2024-10-03 20:26
Second Decision	2024-11-11 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-11-12 02:48
Articles in Press	2024-11-12 02:48
Publication Fee Transferred	2024-11-14 14:15
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-11-26 05:52
Publish the Manuscript Online	2024-11-29 03:06

ISSN	2220-3192 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pharmacology & Pharmacy
Manuscript Type	Basic Study
Article Title	Pre-terminal protein, the achilles heel of Adenoviridae: Implications for adenoviral infections
Manuscript Source	Unsolicited Manuscript
All Author List	Harold A Walsh
Funding Agency and Grant Number
Corresponding Author	Harold A Walsh, PhD, Division of Pharmacology, Rhodes University, Drostdy Road, Grahamstown 6139, Eastern Cape, South Africa. h.walsh@ru.ac.za
Key Words	Thomsen-Friedenreich antigen; Adenoviral; Pre-terminal protein; Spodoptera frugiperda cells; Protein priming mechanism; Glycosylation
Core Tip	A key objective in antiviral research is to recognize appropriate targets within the viral life cycle that are independent of normal host cellular functions. Adenoviruses utilize a ‘unique’ protein priming mechanism to replicate that requires a viral protein, pTP, for the initiation of replication. pTP thus appears to be a likely target for chemotherapeutic intervention. The finding that glycosylation of cloned pTP (in situ) in insect cells (Sf-9) prevents binding to ssDNA (in vitro) could prove useful in developing an effective treatment that facilitates the generation of an abortive adenoviral replication complex that would adversely affect HAd virulence and propagation.
Publish Date	2024-11-29 03:06
Citation	<p>Walsh HA. Pre-terminal protein, the achilles heel of Adenoviridae: Implications for adenoviral infections. <i>World J Pharmacol</i> 2024; 13(2): 97723</p>
URL	https://www.wjgnet.com/2220-3192/full/v13/i2/97723.htm
DOI	https://dx.doi.org/10.5497/wjp.v13.i2.97723

Full Article (PDF)	WJP-13-97723-with-cover.pdf
Manuscript File	97723_Auto_Edited_033232.docx
Answering Reviewers	97723-answering-reviewers.pdf
Audio Core Tip	97723-audio.m4a
Biostatistics Review Certificate	97723-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	97723-conflict-of-interest-statement.pdf
Copyright License Agreement	97723-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	97723-non-native-speakers.pdf
Peer-review Report	97723-peer-reviews.pdf
Scientific Misconduct Check	97723-scientific-misconduct-check.png
Scientific Editor Work List	97723-scientific-editor-work-list.pdf
CrossCheck Report	97723-crosscheck-report.pdf