Publication Name	World Journal of Stem Cells
Manuscript ID	97756
Country	South Korea

Received	2024-06-07 06:20
Peer-Review Started	2024-06-07 06:20
To Make the First Decision
Return for Revision	2024-07-30 06:44
Revised	2024-08-29 07:45
Second Decision	2024-10-08 23:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-16 07:49
Articles in Press	2024-10-16 07:49
Publication Fee Transferred	2024-10-22 00:33
Edit the Manuscript by Language Editor	2024-11-04 07:12
Typeset the Manuscript	2024-11-06 08:06
Publish the Manuscript Online	2024-11-26 10:21

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Exosome-based strategy against colon cancer using small interfering RNA-loaded vesicles targeting soluble a proliferation-inducing ligand
Manuscript Source	Unsolicited Manuscript
All Author List	Hyung-Jin Kim, Do Sang Lee, Jung Hyun Park, Ha-Eun Hong, Ho Joong Choi, Ok-Hee Kim and Say-June Kim
Funding Agency and Grant Number	Funding Agency Grant Number National Research Foundation of Korea NRF-2018R1D1A1B07047144
Corresponding Author	Say-June Kim, PhD, Professor, Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, South Korea. sayjunekim@catholic.ac.kr
Key Words	Colon cancer; Drug delivery system; Exosome; Soluble a proliferation-inducing ligand; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Targeted therapy
Core Tip	This study investigates the potential of bioengineered exosomes (Exs), specifically small interfering peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 RNA-loaded soluble a proliferation-inducing ligand-targeted Exs, in treating colon cancer. By targeting soluble A proliferation-inducing ligand and delivering small interfering peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, these modified Exs demonstrated superior efficacy in inhibiting tumor growth and epithelial-mesenchymal transition compared to standard Ex treatments. The findings highlight the promise of the novel targeted Exs, offering insights into the enhanced targetability and anticancer effectiveness of Ex-based therapies in oncological applications.
Publish Date	2024-11-26 10:21
Citation	<p>Kim HJ, Lee DS, Park JH, Hong HE, Choi HJ, Kim OH, Kim SJ. Exosome-based strategy against colon cancer using small interfering RNA-loaded vesicles targeting soluble a proliferation-inducing ligand. <i>World J Stem Cells</i> 2024; 16(11): 956-973</p>
URL	https://www.wjgnet.com/1948-0210/full/v16/i11/956.htm
DOI	https://dx.doi.org/10.4252/wjsc.v16.i11.956

Full Article (PDF)	WJSC-16-956-with-cover.pdf
The ARRIVE Guidelines	97756-The-ARRIVE-Guidelines.pdf
Manuscript File	97756_Auto_Edited_081947.docx
Answering Reviewers	97756-answering-reviewers.pdf
Audio Core Tip	97756-audio.m4a
Biostatistics Review Certificate	97756-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	97756-conflict-of-interest-statement.pdf
Copyright License Agreement	97756-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	97756-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	97756-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	97756-non-native-speakers.pdf
Peer-review Report	97756-peer-reviews.pdf
Scientific Misconduct Check	97756-scientific-misconduct-check.png
Scientific Editor Work List	97756-scientific-editor-work-list.pdf
CrossCheck Report	97756-crosscheck-report.pdf