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12/12/2024 12:06:17 PM | Browse: 300 | Download: 970
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Received |
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2024-06-25 15:54 |
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Peer-Review Started |
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2024-06-25 15:54 |
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First Decision by Editorial Office Director |
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2024-09-10 01:44 |
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Return for Revision |
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2024-09-10 01:44 |
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Revised |
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2024-09-17 20:05 |
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Publication Fee Transferred |
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2024-10-28 15:55 |
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Second Decision by Editor |
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2024-10-22 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-10-22 08:13 |
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Articles in Press |
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2024-10-22 08:13 |
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Edit the Manuscript by Language Editor |
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2024-11-05 02:26 |
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Typeset the Manuscript |
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2024-11-12 01:42 |
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Publish the Manuscript Online |
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2024-12-12 09:30 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Dysregulation of genes involved in the long-chain fatty acid transport in pancreatic ductal adenocarcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Radu Cristian Poenaru, Elena Milanesi, Andrei Marian Niculae, Anastasia-Maria Dobre, Catalina Vladut, Mihai Ciocîrlan, Daniel Vasile Balaban, Vlad Herlea, Maria Dobre and Mihail Eugen Hinescu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Romanian Ministry of Research, Innovation and Digitization |
PN23.16.02.04 |
| Romanian Ministry of Research, Innovation and Digitization |
31PFE/30.12.2021 |
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| Corresponding Author |
Maria Dobre, PhD, Department of Pathology, Victor Babes National Institute of Pathology, Splaiul Independentei 99-101, Bucharest 050096, Romania. maria_dobre70@yahoo.com |
| Key Words |
Carcinoma, Pancreatic ductal; Fatty acid transport; Gene expression, Biomarkers |
| Core Tip |
In this original article, we show preliminary results of a case-control study in which we analyzed the expression level of nine relevant genes involved in the long-chain fatty acid (FA) import in pancreatic ductal adenocarcinoma (PDAC). We found that three FA transporters (SLC27A2, SLC27A3, and SLC27A4) and two long chain acyl-CoA synthetases genes (ACSL1 and ACSL3) were significantly upregulated in the PDAC tissue compared to the non-tumoral tissue. These data suggest that addressing lipid metabolism through a broad strategy that may impact both tumor cells and the tumor microenvironment could be a beneficial way to treat this malignancy. |
| Publish Date |
2024-12-12 09:30 |
| Citation |
Poenaru RC, Milanesi E, Niculae AM, Dobre AM, Vladut C, Ciocîrlan M, Balaban DV, Herlea V, Dobre M, Hinescu ME. Dysregulation of genes involved in the long-chain fatty acid transport in pancreatic ductal adenocarcinoma. World J Gastrointest Oncol 2025; 17(1): 98409 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i1/98409.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i1.98409 |
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