Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	98409
Country	Romania

Received	2024-06-25 15:54
Peer-Review Started	2024-06-25 15:54
To Make the First Decision
Return for Revision	2024-09-10 01:44
Revised	2024-09-17 20:05
Second Decision	2024-10-22 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-22 08:13
Articles in Press	2024-10-22 08:13
Publication Fee Transferred	2024-10-28 15:55
Edit the Manuscript by Language Editor	2024-11-05 02:26
Typeset the Manuscript	2024-11-12 01:42
Publish the Manuscript Online	2024-12-12 09:30

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Dysregulation of genes involved in the long-chain fatty acid transport in pancreatic ductal adenocarcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Radu Cristian Poenaru, Elena Milanesi, Andrei Marian Niculae, Anastasia-Maria Dobre, Catalina Vladut, Mihai Ciocîrlan, Daniel Vasile Balaban, Vlad Herlea, Maria Dobre and Mihail Eugen Hinescu
Funding Agency and Grant Number	Funding Agency Grant Number Romanian Ministry of Research, Innovation and Digitization PN23.16.02.04 Romanian Ministry of Research, Innovation and Digitization 31PFE/30.12.2021
Corresponding Author	Maria Dobre, PhD, Department of Pathology, Victor Babes National Institute of Pathology, Splaiul Independentei 99-101, Bucharest 050096, Romania. maria_dobre70@yahoo.com
Key Words	Carcinoma, Pancreatic ductal; Fatty acid transport; Gene expression, Biomarkers
Core Tip	In this original article, we show preliminary results of a case-control study in which we analyzed the expression level of nine relevant genes involved in the long-chain fatty acid (FA) import in pancreatic ductal adenocarcinoma (PDAC). We found that three FA transporters (SLC27A2, SLC27A3, and SLC27A4) and two long chain acyl-CoA synthetases genes (ACSL1 and ACSL3) were significantly upregulated in the PDAC tissue compared to the non-tumoral tissue. These data suggest that addressing lipid metabolism through a broad strategy that may impact both tumor cells and the tumor microenvironment could be a beneficial way to treat this malignancy.
Publish Date	2024-12-12 09:30
Citation	<p>Poenaru RC, Milanesi E, Niculae AM, Dobre AM, Vladut C, Ciocîrlan M, Balaban DV, Herlea V, Dobre M, Hinescu ME. Dysregulation of genes involved in the long-chain fatty acid transport in pancreatic ductal adenocarcinoma. <i>World J Gastrointest Oncol</i> 2025; 17(1): 98409</p>
URL	https://www.wjgnet.com/1948-5204/full/v17/i1/98409.htm
DOI	https://dx.doi.org/10.4251/wjgo.v17.i1.98409

Full Article (PDF)	WJGO-17-98409-with-cover.pdf
Manuscript File	98409_Auto_Edited_055145.docx
Answering Reviewers	98409-answering-reviewers.pdf
Audio Core Tip	98409-audio.mp4
Biostatistics Review Certificate	98409-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	98409-conflict-of-interest-statement.pdf
Copyright License Agreement	98409-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	98409-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	98409-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	98409-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	98409-non-native-speakers.pdf
Peer-review Report	98409-peer-reviews.pdf
Scientific Misconduct Check	98409-scientific-misconduct-check.png
Scientific Editor Work List	98409-scientific-editor-work-list.pdf
CrossCheck Report	98409-crosscheck-report.png
CrossCheck Report	98409-crosscheck-report.pdf