Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	98468
Country	Bahrain

Received	2024-06-26 22:01
Peer-Review Started	2024-06-26 22:01
To Make the First Decision
Return for Revision	2024-07-28 22:37
Revised	2024-07-29 10:22
Second Decision	2024-08-01 02:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-08-01 09:41
Articles in Press	2024-08-01 09:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-08-06 00:20
Publish the Manuscript Online	2024-08-30 07:27

ISSN	2219-2808 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Pediatrics
Manuscript Type	Systematic Reviews
Article Title	Decoding the genetic landscape of autism: A comprehensive review
Manuscript Source	Invited Manuscript
All Author List	Mohammed Al-Beltagi, Nermin Kamal Saeed, Adel Salah Bediwy, Eman A Bediwy and Reem Elbeltagi
Funding Agency and Grant Number
Corresponding Author	Mohammed Al-Beltagi, MBChB, MD, PhD, Academic Editor, Chairman, Full Professor, Research Scientist, Department of Pediatric, Faculty of Medicine, Tanta University, Al-Bahr Street, The Medical Complex, Tanta ‎ 31511‎, Alghrabia, Egypt. mbelrem@hotmail.com
Key Words	Autism spectrum disorder; Genetics; Epigenetics; Clustered Regularly Interspaced Short Palindromic Repeats-Cas9; Gene-environment interactions; Personalized medicine
Core Tip	This review synthesizes current knowledge on the genetic and epigenetic factors contributing to autism spectrum disorder (ASD). It highlights the complexity of ASD's genetic architecture and the role of epigenetic mechanisms such as DNA methylation and non-coding RNAs in disease pathogenesis. Emerging technologies like Clustered Regularly Interspaced Short Palindromic Repeats-Cas9 and advanced bioinformatics are pivotal for advancing our understanding of ASD. Collaborative research efforts are crucial for integrating diverse disciplines and international data, aiming to translate genetic insights into personalized therapies. Addressing unresolved questions and ethical considerations will be essential for maximizing the clinical utility of genetic discoveries in improving outcomes for individuals with ASD.
Publish Date	2024-08-30 07:27
Citation	<p>Al-Beltagi M, Saeed NK, Bediwy AS, Bediwy EA, Elbeltagi R. Decoding the genetic landscape of autism: A comprehensive review. <i>World J Clin Pediatr</i> 2024; 13(3): 98468</p>
URL	https://www.wjgnet.com/2219-2808/full/v13/i3/98468.htm
DOI	https://dx.doi.org/10.5409/wjcp.v13.i3.98468

Full Article (PDF)	WJCP-13-98468-with-cover.pdf
PRISMA 2009 Checklist	98468-PRISMA-2009-Checklist.pdf
Manuscript File	98468_Auto_Edited_063218.docx
Answering Reviewers	98468-answering-reviewers.pdf
Audio Core Tip	98468-audio.mp3
Biostatistics Review Certificate	98468-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	98468-conflict-of-interest-statement.pdf
Copyright License Agreement	98468-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	98468-non-native-speakers.pdf
Peer-review Report	98468-peer-reviews.pdf
Scientific Misconduct Check	98468-scientific-misconduct-check.png
Scientific Editor Work List	98468-scientific-editor-work-list.pdf
CrossCheck Report	98468-crosscheck-report.pdf