| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Integrative & Complementary Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection: A natural ingredient strategy
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xin Zhou, Dan Ma, Yi-Xiang He, Jing Jin, Hong-Lian Wang, Yun-Feng Wang, Fan Yang, Jian-Qin Liu, Jie Chen and Zhi Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81900599 |
| Science and Technology Department of Sichuan Province |
2020YFS0376 |
| Science and Technology Program of Hospital of TCM, Southwest Medical University |
2022-CXTD-01 |
|
| Corresponding Author |
Zhi Li, MD, PhD, Professor, Department of Spleen and Stomach Diseases, the Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, No. 1 Xianglin Road, Longmatan District, Luzhou 646000, Sichuan Province, China. lizhi_swmu@126.com |
| Key Words |
Kangfuxin solution; Natural component; Endoscopic submucosal dissection; Esophagus stricture; Fibrosis |
| Core Tip |
This study investigated the therapeutic effects and mechanisms of Kangfuxin solution (KFX) on esophageal stenosis following endoscopic submucosal dissection (ESD). Pigs underwent full circumferential ESD and received KFX treatment for 21 days. Endoscopic examinations assessed esophageal repair, while the expression of α-smooth muscle actin-2, fibronectin, and collagen I was evaluated. Profibrotic signaling was analyzed, including transforming growth factor (TGF)-β1, Smad2/3, and phosphor-smad2/3. In vitro, TGF-β1 induced a fibrotic microenvironment in primary esophageal fibroblasts, and KFX treatment reduced the expression of fibrotic markers in these cells. |
| Publish Date |
2024-12-09 10:40 |
| Citation |
<p>Zhou X, Ma D, He YX, Jin J, Wang HL, Wang YF, Yang F, Liu JQ, Chen J, Li Z. Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection: A natural ingredient strategy. <i>World J Gastroenterol</i> 2025; 31(1): 98561</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i1/98561.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i1.98561 |
