Publication Name	World Journal of Diabetes
Manuscript ID	98641
Country	China

Received	2024-07-01 11:48
Peer-Review Started	2024-07-01 11:48
To Make the First Decision
Return for Revision	2024-08-15 04:46
Revised	2024-08-27 11:45
Second Decision	2024-10-09 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-22 09:46
Articles in Press	2024-10-22 09:46
Publication Fee Transferred	2024-10-22 10:46
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-10-25 08:53
Publish the Manuscript Online	2024-11-18 03:30

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Pediatrics
Manuscript Type	Retrospective Study
Article Title	COVID-19 infection and inactivated vaccination: Impacts on clinical and immunological profiles in Chinese children with type 1 diabetes
Manuscript Source	Unsolicited Manuscript
All Author List	Zhen-Ran Xu, Li Xi, Jing Wu, Jin-Wen Ni, Fei-Hong Luo and Miao-Ying Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Key Research and Development Program of China 2021YFC2701900 National Key Research and Development Program of China 2016YFC1305300
Corresponding Author	Miao-Ying Zhang, MD, Assistant Professor, Department of Pediatric Endocrinology and Inherited Metabolic Diseases, National Children’s Medical Center, Children's Hospital of Fudan University, No. 399 Wan Yuan Road, Minhang District, Shanghai 201102, China. miaoyingzhang@126.com
Key Words	COVID-19 infection; Diabetic ketoacidosis; Type 1 diabetes; Vaccination; Immune profiles
Core Tip	Much remains unknown regarding the association between the infection and vaccination of coronavirus disease 2019 (COVID-19) and the progression of type 1 diabetes (T1D). In this study, we analyzed the features of newly diagnosed T1D children after COVID-19 infection and inactivated vaccination in China. A history of COVID-19 infection was associated with a greater risk of DKA at the onset of T1D, whereas inactivated vaccination significantly lowered DKA incidence. Furthermore, HLA-DR3 positive children with COVID-19 infection had earlier T1D onset and lower fasting C-peptide levels, suggesting that COVID-19 infection predisposes HLA-DR3 positive children to severe T1D.
Publish Date	2024-11-18 03:30
Citation	<p>Xu ZR, Xi L, Wu J, Ni JW, Luo FH, Zhang MY. COVID-19 infection and inactivated vaccination: Impacts on clinical and immunological profiles in Chinese children with type 1 diabetes. <i>World J Diabetes</i> 2024; 15(12): 2276-2284</p>
URL	https://www.wjgnet.com/1948-9358/full/v15/i12/2276.htm
DOI	https://dx.doi.org/10.4239/wjd.v15.i12.2276

Full Article (PDF)	WJD-15-2276-with-cover.pdf
Manuscript File	98641_Auto_Edited_055112.docx
Answering Reviewers	98641-answering-reviewers.pdf
Audio Core Tip	98641-audio.m4a
Biostatistics Review Certificate	98641-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	98641-conflict-of-interest-statement.pdf
Copyright License Agreement	98641-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	98641-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	98641-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	98641-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	98641-non-native-speakers.pdf
Supplementary Material	98641-supplementary-material.pdf
Peer-review Report	98641-peer-reviews.pdf
Scientific Misconduct Check	98641-scientific-misconduct-check.png
Scientific Editor Work List	98641-scientific-editor-work-list.pdf
CrossCheck Report	98641-crosscheck-report.png
CrossCheck Report	98641-crosscheck-report.pdf