Publication Name	World Journal of Gastroenterology
Manuscript ID	98758
Country	India

Received	2024-08-19 07:57
Peer-Review Started	2024-07-04 16:33
To Make the First Decision
Return for Revision	2024-11-10 04:36
Revised	2024-11-22 04:01
Second Decision	2024-12-02 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-02 06:00
Articles in Press	2024-12-02 06:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-12-12 07:58
Publish the Manuscript Online	2024-12-20 03:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Can Emax and platelet count truly differentiate between benign and malignant liver lesions?
Manuscript Source	Unsolicited Manuscript
All Author List	Manjeet Kumar Goyal and Omesh Goyal
Funding Agency and Grant Number
Corresponding Author	Manjeet Kumar Goyal, MD, Postdoctoral Fellow, Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, Ansari Nagar East, New Delhi 110029, Delhi, India. manjeetgoyal@gmail.com
Key Words	Emax; Platelet count; Benign liver lesions; Malignant liver lesions; Hepatocellular carcinoma; Cirrhosis; Diagnostic biomarkers; Shear wave elastography; Methodological limitations; Clinical utility
Core Tip	This letter critically analyzes the Jiang et al's study to differentiate benign and malignant liver lesions using Emax and platelet count, but faces critical methodological issues. The lack of transparency in Emax measurement, inadequate control for confounding variables, and absence of clinically relevant thresholds limit the study’s practical applicability. The nomogram's heavy reliance on Emax is questionable due to its attenuation in hepatocellular carcinoma patients with cirrhosis, further confounding the results. Future research should employ rigorous methodologies, including larger, diverse cohorts and standardized protocols, to validate these biomarkers' clinical utility and ensure their reliability in practice.
Publish Date	2024-12-20 03:53
Citation	<p>Goyal MK, Goyal O. Can Emax and platelet count truly differentiate between benign and malignant liver lesions? <i>World J Gastroenterol</i> 2025; 31(3): 98758</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i3/98758.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i3.98758

Full Article (PDF)	WJG-31-98758-with-cover.pdf
Manuscript File	98758_Auto_Edited_013806.docx
Answering Reviewers	98758-answering-reviewers.pdf
Audio Core Tip	98758-audio.mp4
Conflict-of-Interest Disclosure Form	98758-conflict-of-interest-statement.pdf
Copyright License Agreement	98758-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	98758-non-native-speakers.pdf
Peer-review Report	98758-peer-reviews.pdf
Scientific Misconduct Check	98758-scientific-misconduct-check.png
Scientific Editor Work List	98758-scientific-editor-work-list.pdf
CrossCheck Report	98758-crosscheck-report.png
CrossCheck Report	98758-crosscheck-report.pdf