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11/22/2024 10:46:19 AM | Browse: 263 | Download: 638
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Received |
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2024-07-10 09:45 |
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Peer-Review Started |
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2024-07-10 09:45 |
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First Decision by Editorial Office Director |
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2024-09-18 04:03 |
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Return for Revision |
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2024-09-18 04:03 |
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Revised |
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2024-09-24 11:26 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-10-11 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-10-11 08:48 |
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Articles in Press |
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2024-10-11 08:48 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-10-14 03:10 |
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Publish the Manuscript Online |
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2024-10-21 07:03 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Suppression of hepatic steatosis in non-alcoholic steatohepatitis model by modified Xiaoyao San formula: Evidence, mechanisms and perspective
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Nabil Eid, Payal Bhatnagar, Li-Li Chan and Marina Garcia-Macia |
| Funding Agency and Grant Number |
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| Corresponding Author |
Nabil Eid, MD, PhD, Assistant Professor, Department of Anatomy, Division of Human Biology, School of Medicine, IMU University, Bukit Jalil, Kuala Lumpur 57000, Malaysia. nabilsaleheid@imu.edu.my |
| Key Words |
Alpha smooth muscle actin; Lipophagy; Autophagy; Phosphatase and tensin homolog; Adenosine 5’-monophosphate-activated protein kinase; Androgen; Inflammation; Xiaoyao San; Liver; Steatosis |
| Core Tip |
Modified Xiaoyao San (MXS) formula has hepato-protective effects in a male rat model of non-alcoholic steatohepatitis (NASH) via suppression of steatosis and inflammation. These protective effects are related to several mechanisms, including the regulation of sex hormone metabolism, androgen upregulation, adenosine 5’-monophosphate-activated protein kinase activation, and enhanced phosphatase and tensin homolog expression. A deeper understanding of the mechanisms behind MXS-induced reduction of hepatic steatosis could assist in the treatment of NASH and related diseases. |
| Publish Date |
2024-10-21 07:03 |
| Citation |
Eid N, Bhatnagar P, Chan LL, Garcia-Macia M. Suppression of hepatic steatosis in non-alcoholic steatohepatitis model by modified Xiaoyao San formula: Evidence, mechanisms and perspective. World J Hepatol 2024; 16(10): 1208-1212 |
| URL |
https://www.wjgnet.com/1948-5182/full/v16/i10/1208.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v16.i10.1208 |
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