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2/28/2025 11:47:27 AM | Browse: 106 | Download: 94
Publication Name World Journal of Diabetes
Manuscript ID 98995
Country China
Received
2024-07-11 11:05
Peer-Review Started
2024-07-11 11:05
To Make the First Decision
Return for Revision
2024-11-26 10:24
Revised
2024-12-09 11:20
Second Decision
2025-01-15 03:15
Accepted by Journal Editor-in-Chief
2025-01-20 09:15
Accepted by Executive Editor-in-Chief
2025-01-23 09:18
Articles in Press
2025-01-23 09:18
Publication Fee Transferred
2024-12-12 03:17
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-02-06 02:49
Publish the Manuscript Online
2025-02-28 10:46
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry & Molecular Biology
Manuscript Type Minireviews
Article Title Intracellular calcium channels: Potential targets for type 2 diabetes mellitus?
Manuscript Source Unsolicited Manuscript
All Author List Jia-Xuan Zhu, Zhao-Nan Pan and Dan Li
Funding Agency and Grant Number
Funding Agency Grant Number
Calygene Biotechnology Inc. XT[2016]008@
Corresponding Author Dan Li, PhD, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, No. 18 Chaowang Road, Hangzhou 310014, Zhejiang Province, China. lidan@zjut.edu.cn
Key Words Ion channels; AMP-activated protein kinase; Calcium; Diabetes; Lactic acidosis
Core Tip The applicability and long-term use of drugs for type 2 diabetes mellitus (T2DM) treatment is limited due to their adverse effects. Drugs that activate AMP-activated protein kinase (AMPK) via calcium signaling exhibit fewer adverse effects such as lactic acidosis. However, the potency of these drugs is limited. Therefore, it is necessary to screen novel drugs with high efficacy but few adverse effects. The calcium channels control intracellular calcium flux, which could be potential targets for T2DM treatment via AMPK. This review summarizes 15 calcium channels, and discuss the potential of targeting these calcium channels for T2DM treatment.
Publish Date 2025-02-28 10:46
Citation <p>Zhu JX, Pan ZN, Li D. Intracellular calcium channels: Potential targets for type 2 diabetes mellitus? <i>World J Diabetes</i> 2025; 16(4): 98995</p>
URL https://www.wjgnet.com/1948-9358/full/v16/i4/98995.htm
DOI https://dx.doi.org/10.4239/wjd.v16.i4.98995
Full Article (PDF) WJD-16-98995-with-cover.pdf
Manuscript File 98995_Auto_Edited_040119.docx
Answering Reviewers 98995-answering-reviewers.pdf
Audio Core Tip 98995-audio.mp3
Conflict-of-Interest Disclosure Form 98995-conflict-of-interest-statement.pdf
Copyright License Agreement 98995-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 98995-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate 98995-non-native-speakers.pdf
Peer-review Report 98995-peer-reviews.pdf
Journal Editor-in-Chief Review Report 98995-journal-editor-in-chief.pdf
Scientific Misconduct Check 98995-scientific-misconduct-check.png
Scientific Editor Work List 98995-scientific-editor-work-list.pdf
CrossCheck Report 98995-crosscheck-report.pdf