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2/28/2025 11:47:27 AM | Browse: 106 | Download: 94
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2024-07-11 11:05 |
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2024-07-11 11:05 |
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2024-11-26 10:24 |
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2024-12-09 11:20 |
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2025-01-15 03:15 |
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Accepted by Journal Editor-in-Chief |
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2025-01-20 09:15 |
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Accepted by Executive Editor-in-Chief |
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2025-01-23 09:18 |
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Articles in Press |
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2025-01-23 09:18 |
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2025-02-06 02:49 |
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2025-02-28 10:46 |
ISSN |
1948-9358 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Biochemistry & Molecular Biology |
Manuscript Type |
Minireviews |
Article Title |
Intracellular calcium channels: Potential targets for type 2 diabetes mellitus?
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Jia-Xuan Zhu, Zhao-Nan Pan and Dan Li |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Calygene Biotechnology Inc. |
XT[2016]008@ |
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Corresponding Author |
Dan Li, PhD, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, No. 18 Chaowang Road, Hangzhou 310014, Zhejiang Province, China. lidan@zjut.edu.cn |
Key Words |
Ion channels; AMP-activated protein kinase; Calcium; Diabetes; Lactic acidosis |
Core Tip |
The applicability and long-term use of drugs for type 2 diabetes mellitus (T2DM) treatment is limited due to their adverse effects. Drugs that activate AMP-activated protein kinase (AMPK) via calcium signaling exhibit fewer adverse effects such as lactic acidosis. However, the potency of these drugs is limited. Therefore, it is necessary to screen novel drugs with high efficacy but few adverse effects. The calcium channels control intracellular calcium flux, which could be potential targets for T2DM treatment via AMPK. This review summarizes 15 calcium channels, and discuss the potential of targeting these calcium channels for T2DM treatment. |
Publish Date |
2025-02-28 10:46 |
Citation |
<p>Zhu JX, Pan ZN, Li D. Intracellular calcium channels: Potential targets for type 2 diabetes mellitus? <i>World J Diabetes</i> 2025; 16(4): 98995</p> |
URL |
https://www.wjgnet.com/1948-9358/full/v16/i4/98995.htm |
DOI |
https://dx.doi.org/10.4239/wjd.v16.i4.98995 |
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