Publication Name	World Journal of Diabetes
Manuscript ID	98995
Country	China

Received	2024-07-11 11:05
Peer-Review Started	2024-07-11 11:05
To Make the First Decision
Return for Revision	2024-11-26 10:24
Revised	2024-12-09 11:20
Second Decision	2025-01-15 03:15
Accepted by Journal Editor-in-Chief	2025-01-20 09:15
Accepted by Executive Editor-in-Chief	2025-01-23 09:18
Articles in Press	2025-01-23 09:18
Publication Fee Transferred	2024-12-12 03:17
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-02-06 02:49
Publish the Manuscript Online	2025-02-28 10:46

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Minireviews
Article Title	Intracellular calcium channels: Potential targets for type 2 diabetes mellitus?
Manuscript Source	Unsolicited Manuscript
All Author List	Jia-Xuan Zhu, Zhao-Nan Pan and Dan Li
Funding Agency and Grant Number	Funding Agency Grant Number Calygene Biotechnology Inc. XT[2016]008@
Corresponding Author	Dan Li, PhD, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, No. 18 Chaowang Road, Hangzhou 310014, Zhejiang Province, China. lidan@zjut.edu.cn
Key Words	Ion channels; AMP-activated protein kinase; Calcium; Diabetes; Lactic acidosis
Core Tip	The applicability and long-term use of drugs for type 2 diabetes mellitus (T2DM) treatment is limited due to their adverse effects. Drugs that activate AMP-activated protein kinase (AMPK) via calcium signaling exhibit fewer adverse effects such as lactic acidosis. However, the potency of these drugs is limited. Therefore, it is necessary to screen novel drugs with high efficacy but few adverse effects. The calcium channels control intracellular calcium flux, which could be potential targets for T2DM treatment via AMPK. This review summarizes 15 calcium channels, and discuss the potential of targeting these calcium channels for T2DM treatment.
Publish Date	2025-02-28 10:46
Citation	<p>Zhu JX, Pan ZN, Li D. Intracellular calcium channels: Potential targets for type 2 diabetes mellitus? <i>World J Diabetes</i> 2025; 16(4): 98995</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i4/98995.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i4.98995

Full Article (PDF)	WJD-16-98995-with-cover.pdf
Manuscript File	98995_Auto_Edited_040119.docx
Answering Reviewers	98995-answering-reviewers.pdf
Audio Core Tip	98995-audio.mp3
Conflict-of-Interest Disclosure Form	98995-conflict-of-interest-statement.pdf
Copyright License Agreement	98995-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	98995-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	98995-non-native-speakers.pdf
Peer-review Report	98995-peer-reviews.pdf
Journal Editor-in-Chief Review Report	98995-journal-editor-in-chief.pdf
Scientific Misconduct Check	98995-scientific-misconduct-check.png
Scientific Editor Work List	98995-scientific-editor-work-list.pdf
CrossCheck Report	98995-crosscheck-report.pdf