Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	99188
Country	China

Received	2024-07-16 06:12
Peer-Review Started	2024-07-16 06:12
To Make the First Decision
Return for Revision	2024-10-11 09:52
Revised	2024-11-08 04:49
Second Decision	2025-01-15 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-15 07:58
Articles in Press	2025-01-15 07:58
Publication Fee Transferred	2024-11-18 10:36
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-31 07:44
Publish the Manuscript Online	2025-03-25 16:18

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Impact of SLC16A8 on tumor microenvironment and angiogenesis in colorectal cancer: New therapeutic target insights
Manuscript Source	Unsolicited Manuscript
All Author List	Hong-Peng Tian, Zhong-Xiang Xiao, Bo-Wen Su, Yi-Xuan Li, Hong Peng and Chang-Yuan Meng
Funding Agency and Grant Number	Funding Agency Grant Number Nanchong Science and Technology Plan Project 23JCYJPT0064 Project of Sichuan Provincial Administration of Traditional Chinese Medicine 2024MS590
Corresponding Author	Hong Peng, Doctor, Doctor, Doctor, Department of Anorectal surgery, Nanchong Central Hospital, The Second clinical Medical College, North Sichuan Medical College, No. 97 Renmin South Road, Shunqing District, Nanchong, Sichuan 637000, China., Nanchong 637000, Sichuan Province, China. p1041910523@126.com
Key Words	SLC16A8; Colorectal cancer; Hypoxia; Glycolysis; Angiogenesis
Core Tip	Hypoxic SLC16A8 upregulated glycolysis factors in cancer cells. Co-culture with HUVEC increased endothelial-mesenchymal transition in endothelial cells. Knockdown reversed phenotypes in both cell types. In vivo, SLC16A8 inhibition reduced tumor growth and angiogenesis, and enhanced apoptosis.
Publish Date	2025-03-25 16:18
Citation	<p>Tian HP, Xiao ZX, Su BW, Li YX, Peng H, Meng CY. Impact of SLC16A8 on tumor microenvironment and angiogenesis in colorectal cancer: New therapeutic target insights. <i>World J Gastrointest Oncol</i> 2025; 17(4): 99188</p>
URL	https://www.wjgnet.com/1948-5204/full/v17/i4/99188.htm
DOI	https://dx.doi.org/10.4251/wjgo.v17.i4.99188

Full Article (PDF)	WJGO-17-99188-with-cover.pdf
The ARRIVE Guidelines	99188-The-ARRIVE-Guidelines.pdf
Manuscript File	99188_Auto_Edited_021612.docx
Answering Reviewers	99188-answering-reviewers.pdf
Audio Core Tip	99188-audio.MP3
Biostatistics Review Certificate	99188-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	99188-conflict-of-interest-statement.pdf
Copyright License Agreement	99188-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	99188-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	99188-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	99188-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	99188-non-native-speakers.pdf
Peer-review Report	99188-peer-reviews.pdf
Scientific Misconduct Check	99188-scientific-misconduct-check.png
Scientific Editor Work List	99188-scientific-editor-work-list.pdf
CrossCheck Report	99188-crosscheck-report.png
CrossCheck Report	99188-crosscheck-report.pdf