Publication Name	World Journal of Experimental Medicine
Manuscript ID	99239
Country	India

Received	2024-07-18 14:48
Peer-Review Started	2024-07-18 14:48
To Make the First Decision
Return for Revision	2024-08-15 07:17
Revised	2024-08-22 02:13
Second Decision	2024-08-27 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-08-27 13:04
Articles in Press	2024-08-27 13:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-09-19 08:05
Publish the Manuscript Online	2024-10-31 07:40

ISSN	2220-315x (online)
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Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Melanocortin 4 receptor mutation in obesity
Manuscript Source	Invited Manuscript
All Author List	Gumpeny R Sridhar and Lakshmi Gumpeny
Funding Agency and Grant Number
Corresponding Author	Gumpeny R Sridhar, FRCP (Hon), Adjunct Professor, Department of Endocrinology and Diabetes, Endocrine and Diabetes Centre, 15-12-15 Krishnanagar, Visakhapatnam 530002, Andhra Pradesh, India. sridharvizag@gmail.com
Key Words	Leptin-melanocortin pathway; Downstream; G protein; Cyclic AMP; Mutation; Obesity syndromes; Screening; Setmelanotide
Core Tip	The leptin-melanocortin pathway regulates energy balance and body weight. Melanocortin-4 receptor (MC4R) plays a key role in this pathway by reducing hunger, inducing satiety and increasing energy expenditure. Mutations of MC4R result in obesity and hyperphagia in childhood. Setmelanotide is an MC4R agonist approved for use in obesity caused by leptin-melanocortin pathway dysfunction.
Publish Date	2024-10-31 07:40
Citation	<p>Sridhar GR, Gumpeny L. Melanocortin 4 receptor mutation in obesity. <i>World J Exp Med</i> 2024; 14(4): 99239</p>
URL	https://www.wjgnet.com/2220-315x/full/v14/i4/99239.htm
DOI	https://dx.doi.org/10.5493/wjem.v14.i4.99239

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