| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qin Wang, Qing-Rong Li, Lei Xu, Zi-Chun Yuan, Xiao Liu, Mao-Ju Tang, Man Luo, Xiao-Wu Zhong, Qiang Ma and Xiao-Lan Guo |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific Research Development Plan Project or the Scientific Research Foundation for Advanced Talents, Affiliated Hospital of North Sichuan Medical College |
No. 2023MPZK017, 2023ZD001, 2023-2ZD002, 2023GC009 |
| Science and Technology Support Program of Nanchong |
No. 22SXQT0001 |
| Youth Medical Innovation Research Project, or Medical Research Project of Sichuan Province |
No. Q23047 and No. S23020 |
| Development of a Scientific Research Plan for the Doctoral Scientific Research Foundation of the North Sichuan Medical College |
No. CBY22-ZDA03 |
|
| Corresponding Author |
Xiao-Lan Guo, MD, PhD, Professor, Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, No. 1 South Maoyuan Road, Shunqing District, Nanchong 637000, Sichuan Province, China. alan5200@hotmail.com |
| Key Words |
Esophageal squamous cell carcinoma; BIBR1532; Human telomerase reverse transcriptase; DNA damage response; Telomere-binding proteins |
| Core Tip |
BIBR1532 inhibited proliferation and metastasis of esophageal squamous cell carcinoma (ESCC) cells in a dose-dependent manner, which also effectively blocked the growth of ESCC in tumor-bearing nude mouse model. Mechanistically, BIBR1532 downregulated the expression of telomere-binding proteins, upregulated the expression of phosphorylated histone H2AX, ataxia telangiectasia and Rad3-related protein/check point kinase 1 (CHK-1) and ataxia-telangiectasia mutated gene/CHK2 pathways. The in vitro and in vivo studies showed that BIBR1532 is a potential chemotherapeutic drug for ESCC. |
| Publish Date |
2024-12-12 09:30 |
| Citation |
<p>Wang Q, Li QR, Xu L, Yuan ZC, Liu X, Tang MJ, Luo M, Zhong XW, Ma Q, Guo XL. BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation. <i>World J Gastrointest Oncol</i> 2025; 17(1): 99376</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i1/99376.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i1.99376 |
