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11/19/2014 3:22:00 PM | Browse: 731 | Download: 1549
Publication Name World Journal of Immunology
Manuscript ID 9950
Country/Territory Japan
Received
2014-03-05 20:27
Peer-Review Started
2014-03-06 08:59
To Make the First Decision
2014-03-26 15:24
Return for Revision
2014-05-12 14:18
Revised
2014-05-17 12:13
Second Decision
2014-07-17 14:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-07-17 14:36
Articles in Press
2014-07-17 14:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-11-11 16:16
Publish the Manuscript Online
2014-11-19 15:06
ISSN 2219-2824 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Immunology
Manuscript Type Review
Article Title Immunological aspects of drug-induced liver injury
Manuscript Source Invited Manuscript
All Author List Kazuto Tajiri and Yukihiro Shimizu
Funding Agency and Grant Number
Corresponding Author Yukihiro Shimizu, MD, PhD, Gastroenterology Unit, Nanto Municipal Hospital, Nanto, Toyama 932-0211, Japan. rsf14240@nifty.com
Key Words Immune cells; Cytokine; Human leukocyte antigen; Innate immunity; Drug-induced liver injury
Core Tip Drug-induced liver injury (DILI) is a common liver disease that occurs frequently after drug ingestion. DILI can be classified as predictable or idiosyncratic. The former is dose dependent, has a short latency period, and results from direct toxicity of the drug or its metabolite(s). Idiosyncratic DILI may be more problematic because it is usually unpredictable and is found more frequently in the clinical setting. This type of DILI is due to an allergic reaction or the toxicity of metabolites generated via individual drug metabolism reactions. Various factors, such as environmental, genetic and immunological reactions, may be associated with adduct formation and the onset of DILI. This review summarizes current knowledge on the immunological aspects of DILI, including its pathogenesis, diagnosis and treatment.
Publish Date 2014-11-19 15:06
Citation Tajiri K, Shimizu Y. Immunological aspects of drug-induced liver injury. World J Immunol 2014; 4(3): 149-157
URL http://www.wjgnet.com/2219-2824/full/v4/i3/149.htm
DOI http://dx.doi.org/10.5411/wji.v4.i3.149
Full Article (PDF) WJI-4-149.pdf
Full Article (Word) WJI-4-149.doc
Manuscript File 9950-Review.doc
Answering Reviewers 9950-Answering reviewers.pdf
Copyright License Agreement 9950-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 9950-Language certificate.pdf
Peer-review Report 9950-Peer review(s).pdf
Scientific Misconduct Check 9950-CrossCheck.jpg
Scientific Editor Work List 9950-Scientific editor work list.pdf