Publication Name	World Journal of Experimental Medicine
Manuscript ID	99516
Country	Egypt

Received	2024-07-24 09:26
Peer-Review Started	2024-07-24 09:26
To Make the First Decision
Return for Revision	2024-09-02 23:17
Revised	2024-09-17 10:23
Second Decision	2024-10-22 02:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-22 13:50
Articles in Press	2024-10-22 13:50
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-10-30 22:45
Typeset the Manuscript	2024-11-06 07:01
Publish the Manuscript Online	2024-12-26 03:04

ISSN	2220-315x (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Retrospective Cohort Study
Article Title	Prevalence of RUNX1 gene alterations in de novo adult acute myeloid leukemia
Manuscript Source	Invited Manuscript
All Author List	Hoda M Abd El-Ghany, Mona S El Ashry, Mona S Abdellateif, Ahmed Rabea, Nada Sultan and Omnia Y Abd El Dayem
Funding Agency and Grant Number
Corresponding Author	Mona S Abdellateif, MD, PhD, Professor, Department of Cancer Biology, National Cancer Institute, Cairo University, 1 Fom Elkhaligue, cairo 11976, Al Qāhirah, Egypt. mona.sayed@nci.cu.edu.eg
Key Words	Acute myeloid leukemia; Deletion; Disease-free survival; Fluorescence in-situ hybridization; Karyotyping; RUNX1
Core Tip	In the current study, we tried to characterize RUNX1 gene rearrangements and copy number variations in newly diagnosed adult acute myeloid leukemia patients, with emphasis on the impact of clinical, and laboratory features on the outcome. RUNX1 abnormalities were mutually exclusive of NPM1 mutations. RUNX1 abnormalities affected neither patients’ response to treatment nor overall survival.
Publish Date	2024-12-26 03:04
Citation	<p>Abd El-Ghany HM, El Ashry MS, Abdellateif MS, Rabea A, Sultan N, Abd El Dayem OY. Prevalence of RUNX1 gene alterations in de novo adult acute myeloid leukemia. <i>World J Exp Med</i> 2025; 15(1): 99516</p>
URL	https://www.wjgnet.com/2220-315x/full/v15/i1/99516.htm
DOI	https://dx.doi.org/10.5493/wjem.v15.i1.99516

Full Article (PDF)	WJEM-15-99516-with-cover.pdf
STROBE Statement	99516-STROBE-statement.pdf
Manuscript File	99516_Auto_Edited_030542.docx
Answering Reviewers	99516-answering-reviewers.pdf
Audio Core Tip	99516-audio.m4a
Biostatistics Review Certificate	99516-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	99516-conflict-of-interest-statement.pdf
Copyright License Agreement	99516-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s)	99516-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	99516-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	99516-non-native-speakers.pdf
Supplementary Material	99516-supplementary-material.pdf
Peer-review Report	99516-peer-reviews.pdf
Scientific Misconduct Check	99516-scientific-misconduct-check.png
Scientific Editor Work List	99516-scientific-editor-work-list.pdf
CrossCheck Report	99516-crosscheck-report.png
CrossCheck Report	99516-crosscheck-report.pdf